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New animal model of depression using water maze learning situation in mice

Research Project

Project/Area Number 22730593
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Experimental psychology
Research InstitutionHyogo Medical University

Principal Investigator

DOE Nobutaka  兵庫医科大学, 医学部, 非常勤講師 (00434879)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords実験系心理学 / 行動学 / 神経科学 / ストレス / 脳神経疾患 / 動物モデル / うつ病
Research Abstract

We have developed a new animal model of depression by modifying the Morris water maze learning situation in mice. It is generally believed that mice placed in a pool filled with opaque water will learn to escape onto a platform hidden below the water surface. However, if the difficulty of the task is increased, some of the mice gradually cease to swim and become immobile ; this response indicates a depressive state. In this research, the validity of our experimental method as a depression model was verified by demonstrating the phenotypic differences between "nonhelpless" mice(designated"Winner") and "helpless"mice(designated"Loser"). Compared with nonhelpless mice, helpless mice showed lower spontaneous locomotor activity in their home cage. In addition, helpless mice exhibited impaired neurogenesis in the hippocampus and increased serum levels of proinflammatory cytokines, such as IL-1α, IL-1β and TNF-α.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (23 results)

All 2012 2011 2010

All Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (13 results) Book (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Genotoxicity-suppressing effect of aqueous extract of Connarus ruber cortex2011

    • Author(s)
      Nakamura, T., Nakai, M., Ookubo, K., Kitamura, Y., Doe, N., Hattori, S., Murakami, N., Yamamoto, A., Honda, G., & Sasaki, Y. F.
    • Journal Title

      Genes and Environment

      Volume: 33 Pages: 81-88

    • NAID

      10029337315

    • URL

      https://www.jstage.jst.go.jp/browse/jemsge/33/3/_contents/-char/ja/

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunodeficiency reduces neural stem/progenitor cell apoptosis and enhances neurogenesis in the cerebral cortex after stroke2010

    • Author(s)
      Saino, O., Taguchi, A., Nakagomi, T., Nakano-Doi, A., Kashiwamura, S., Doe, N., Nakagomi, N., Soma, T., Yoshikawa, H., Stern, D. M., Okamura, H., & Matsuyama, T.
    • Journal Title

      Journal of Neuroscience Research

      Volume: 88 Issue: 11 Pages: 2385-2397

    • DOI

      10.1002/jnr.22410

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 強制水泳処置が誘発するマウス水迷路学習の獲得障害2010

    • Author(s)
      土江伸誉・鶴田裕文・川尻佳八・高橋励・西口恵・桐山美香
    • Journal Title

      実験動物技術

      Volume: 45 Pages: 3-8

    • NAID

      10026883094

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 行動科学的手法によるうつ動物モデルの有用性2010

    • Author(s)
      土江伸誉
    • Journal Title

      行動科学

      Volume: 48(2) Pages: 1-9

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Behavioral despair during a water maze learning task in mice2010

    • Author(s)
      Doe, N., Takahashi, T., & Kiriyama, M.
    • Journal Title

      Experimental Animals

      Volume: 59 Pages: 191-197

    • NAID

      130000254346

    • URL

      https://www.jstage.jst.go.jp/browse/expanim/59/2/_contents

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] コンナルス(Connarus rubber)抽出物の皮膚への有効性検討2011

    • Author(s)
      中井隆人・西浦英樹・山崎佳代子・中村隆典・本多義昭・土江伸誉・北村佳久
    • Organizer
      日本生薬学会第58回年会
    • Place of Presentation
      昭和大学
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] 水迷路学習場面におけるマウスの行動的絶望-うつ発症の個人差を検討可能な動物モデル-2011

    • Author(s)
      土江伸誉
    • Organizer
      日本動物心理学会第155回例会
    • Place of Presentation
      名古屋ホテル新名
    • Year and Date
      2011-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 水迷路学習場面におけるマウスの行動的絶望-うつ発症の個人差を検討可能な動物モデル-2011

    • Author(s)
      土江伸誉
    • Organizer
      日本動物心理学会第155回例会
    • Place of Presentation
      ホテル新名(名古屋市)
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨髄単核球投与は視床の神経再生を介して脳梗塞後の感覚障害を改善する2011

    • Author(s)
      土居亜紀子・土江伸誉・中込隆之・田片将士・蘆山・金岡伸一・立花久大・田口明彦・松山知弘
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] マウスの行動的絶望と自発活動性との関係2011

    • Author(s)
      土江伸誉
    • Organizer
      日本心理学会第75回大会
    • Place of Presentation
      日本大学
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 水迷路学習場面におけるマウスの行動的絶望と海馬神経細胞新生との関係2011

    • Author(s)
      土江伸誉
    • Organizer
      日本動物心理学会第71回大会
    • Place of Presentation
      慶應義塾大学
    • Related Report
      2011 Final Research Report
  • [Presentation] 4月生まれは本当に得か?-日本の競馬騎手における相対的年齢効果の逆転-2011

    • Author(s)
      土江伸誉
    • Organizer
      日本感情心理学会第19回大会
    • Place of Presentation
      京都光華女子大学
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Edaravone is effective to ameliorate the sensory neurologic deficit developed in chronic phase of cerebral infarction in mice2011

    • Author(s)
      Matsuyama, T., Doe, N., Nakagomi, T., Nakano-Doi, A., Saino, O., Takata, M., Lu, S., Mimura, O., Tachibana, H., Taguchi, A.
    • Organizer
      XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function & Xth International Conference on Quantification of Brain Function and PET, Brain 2011
    • Place of Presentation
      Barcelona, Spain
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 水迷路学習場面におけるマウスの行動的絶望と海馬神経細胞新生との関係2011

    • Author(s)
      土江伸誉
    • Organizer
      日本動物心理学会第71回大会(Animal2011)
    • Place of Presentation
      慶應義塾大学
    • Related Report
      2011 Annual Research Report
  • [Presentation] 水迷路学習場面におけるマウスの行動的絶望-メタンフェタミンに対する感受性-2010

    • Author(s)
      土江伸誉
    • Organizer
      関西心理学会第122回大会
    • Place of Presentation
      兵庫医療大学
    • Year and Date
      2010-11-07
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] CD25-positive T lymphocytes are key immunomodulators of neurogenesis after stroke2010

    • Author(s)
      Matsuyama, T., Saino, O., Nakagomi, T., Nakano-Doi, A., Takata, M., Kashiwamura, S., Doe, N., Nakagomi, N., Mimura, O., & Taguchi, A.
    • Organizer
      7th World Stroke Congress
    • Place of Presentation
      Soeal, Koria
    • Related Report
      2011 Final Research Report
  • [Presentation] 水迷路学習の消去によって誘発されるマウスのうつ的状態2010

    • Author(s)
      土江伸誉
    • Organizer
      日本心理学会第74回大会
    • Place of Presentation
      大阪大学
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 強制水泳処置とオープンスペース水泳処置はマウスに異なるうつ的状態を誘発する2010

    • Author(s)
      土江伸誉
    • Organizer
      日本動物心理学会第69回大会
    • Place of Presentation
      帝京大学
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Book] 『シリーズ心理学研究法第3巻学習・動機・情動』第6章回避・逃避2011

    • Author(s)
      大山正監修・廣中直行編, 廣中直行・澤幸祐・堀耕治・永石高敏・沼田恵太郎・栗原彬・高野裕治・土江伸誉・野村理朗・津田彰・堀内聡・山口拓・富樫廣子・吉岡充弘・佐藤暢哉・山田冨美雄・大平英樹著
    • Publisher
      誠信書房
    • Related Report
      2011 Final Research Report
  • [Book] 回避・逃避『シリーズ心理学研究法第3巻学習・動機・情動』(P.121-140)(大山正監修・廣中直行編)2011

    • Author(s)
      土江伸誉
    • Total Pages
      296
    • Publisher
      誠信書房
    • Related Report
      2011 Annual Research Report
  • [Book] 『K. G.りぶれっとNo.26心理科学研究の最前線』第2章ネズミはうつ病になるか2010

    • Author(s)
      平野哲司・土江伸誉・今西明・一言英文・石暁玲・中見仁美著
    • Publisher
      関西学院大学出版会
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 脳梗塞後うつ病モデル動物及びその使用並びにうつ状態に対する被検薬物及び移植細胞の有効性のスクリーニング方法2012

    • Inventor(s)
      松山知弘・土江伸誉・田口明彦
    • Industrial Property Rights Holder
      財団法人先端医療振興財団
    • Industrial Property Number
      2012-053456
    • Filing Date
      2012-03-09
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Patent(Industrial Property Rights)] 欝モデルマウス作製法2010

    • Inventor(s)
      土江伸誉・桐山美香・谷口泰造
    • Industrial Property Rights Holder
      土江伸誉・谷口泰造・有限会社行動医科学研究所
    • Acquisition Date
      2010-11-05
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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