The application of salivary inflammatory markers to an assessment of stress

• Project/Area Number: 22730597
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Experimental psychology
• Research Institution: National Institute of Occupational Safety and Health, Japan
• Principal Investigator: IZAWA Shuhei 独立行政法人労働安全衛生総合研究所, 作業条件適応研究グループ, 研究員 (00409757)
• Co-Investigator(Renkei-kenkyūsha): SUGAYA Nagisa 公益財団法人東京都医学総合研究所, 依存性薬物プロジェクト, 研究員 (90508425) ; SHIROTSUKI Kentaro 東海学院大学, 人間関係学部, 講師 (50582714) ; YAMADA Chris kosuke 佐賀大学, 医学部, 助教 (70510741) ; SAITO Keisuke 東海大学, 短期大学部・児童教育学科, 准教授 (80442119)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 唾液 / ストレス / 炎症 / インターロイキン6 / C反応性蛋白

Research Abstract

An objective assessment of stress is needed to manage stress and prevent the development of stress-related diseases. In this study, considering the assessment of stress by using salivary inflammatory markers(Interlukine-6(IL-6) and C-reactive protein(CRP)), we investigated salivary IL-6 and CRP secretion in students exposed to acute stress(speech and mental arithmetic tasks) and prolonged stress(two-week teaching practice). IL-6 levels increased in response to both acute stress and prolonged stress while CRP levels acutely increased in response to acute stress tasks but not to prolonged stress. These results indicated that salivary IL-6 was useful for the assessment of stress.

Research Products

• [Journal Article] Adrenal hormone response and psychophysiological correlates under psychosocial stress in individuals with irritable bowel syndrome (2012)
  • Author(s): Sugaya, N., Izawa, S., Kimura, K., Ogawa, N., Yamada, K. C., Shirotsuki, K., Mikami, I., Hirata, K., Nagano, Y., Nomura, S., & Shimada, H
  • Journal Title: International Journal of Psychophysiology Volume: 84 Pages: 39-44
  • Peer Reviewed
• [Presentation] 抑うつ症状と唾液中炎症マーカーの関連:予備的検討 (2011)
  • Author(s): 井澤修平・三木圭一・劉欣欣・小川奈美子
  • Organizer: 第18回日本行動医学学術総会
  • Place of Presentation: 久留米大学
  • Year and Date: 2011-12-10
• [Presentation] 急性ストレスに対する唾液中CRP反応 (2011)
  • Author(s): 山田クリス孝介・井澤修平・菅谷渚・木村健太・小川奈美子・城月健太郎・長野祐一郎・野村忍
  • Organizer: 第18回日本行動医学学術総会
  • Place of Presentation: 久留米大学
  • Year and Date: 2011-12-10
• [Presentation] 学生アスリートの慢性的ストレスによる起床時コルチゾール反応-練習後と休養後の比較検討- (2011)
  • Author(s): 菅生貴之・門岡晋・平田勝士・時國順・小林亜未・井澤修平
  • Organizer: 日本体育学会第62回大会
  • Place of Presentation: 鹿屋体育大学
  • Year and Date: 2011-09-27
• [Presentation] Salivary cortisol and DHEA-S response under acute psychosocial stress in individuals with irritable bowel syndrome (2011)
  • Author(s): Sugaya, N., Izawa, S., Kimura, K., Ogawa, N., Yamada, K. C., Shirotsuki, K., Mikami, I., Hirata, K., Nagano, Y., Nomura, S., & Shimada, H.
  • Organizer: American Psychosomatic Society 69th Annual Scientific Meeting
  • Place of Presentation: Texas, USA
  • Year and Date: 2011-03-11
• [Presentation] Salivary cortisol and DHEA-S response under acute psychosocial stress in individuals with irritable bowel syndrome. (2011)
  • Author(s): Sugaya, N.
  • Organizer: American Psychosomatic Society 69th Annual Scientific Meeting
  • Place of Presentation: Texas, USA
• [Presentation] The effect of chronic stress on male university students in their final examinations (2010)
  • Author(s): Nomura, S., Morishima, M., Migita, M., Mizuno, T., Nozawa, A., Suzuki, I., Izawa, S., & Imai, J
  • Organizer: 10th International Congress of Neuroimmunology
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2010-10-27
• [Presentation] 過敏性腸症候群における心理社会的ストレス負荷時の認知的評価・不安・副腎皮質ホルモンの関連 (2010)
  • Author(s): 菅谷渚・井澤修平・木村健太・小川奈美子・山田クリス孝介・城月健太郎・三上育葉・平田華奈子・長野祐一郎・野村忍・嶋田洋徳
  • Organizer: 日本心理学会第74回大会
  • Place of Presentation: 大阪大学
  • Year and Date: 2010-09-21
• [Presentation] 社会的な刺激への注意と心理社会的ストレスに対する内分泌反応との関連 (2010)
  • Author(s): 木村健太・井澤修平・菅谷渚・小川奈美子・山田クリス孝介・城月健太郎・三上育葉・平田華奈子・長野祐一郎・長谷川寿一
  • Organizer: 日本心理学会第74回大会
  • Place of Presentation: 大阪大学
  • Year and Date: 2010-09-20
• [Presentation] 唾液中コルチゾールを利用したストレス評価(シンポジウム:精神神経内分泌免疫学研究の応用-臨床・ストレス予防への利用-) (2010)
  • Author(s): 井澤修平
  • Organizer: 日本心理学会第74回大会
  • Place of Presentation: 大阪大学
  • Year and Date: 2010-09-20
• [Presentation] Salivary IL-6 and CRP increase in response to acute psychosocial stress (2010)
  • Author(s): Izawa, S., Sugaya, N., Kimura, K., Ogawa, N., Yamada, K. C., Shirotsuki, K., Mikami, I., Hirata, K., Nagano, Y., & Nomura S
  • Organizer: 11th International Congress of Behavioral Medicine
  • Place of Presentation: Washington, D. C., USA.
  • Year and Date: 2010-08-05
• [Presentation] The relationship between cognitive appraisal and adrenal hormone under psychosocial stress in individuals with irritable bowel syndrome (2010)
  • Author(s): Sugaya, N., Izawa, S., Ouchi, Y., Shirotsuki, K., Yamada, C. K., Ogawa, N., Nagano, Y., Nomura, S., & Shimada, H
  • Organizer: 6th World Congress of Behavioral and Cognitive Therapies
  • Place of Presentation: Boston, USA
  • Year and Date: 2010-06-03
• [Presentation] Salivary IL-6 and CRP increase in response to acute psychosocial stress (2010)
  • Author(s): Izawa, S.
  • Organizer: 11th International Congress of Behavioral Medicine
  • Place of Presentation: Washington, D.C., USA
• [Presentation] 唾液中コルチゾールを利用したストレス評価 (2010)
  • Author(s): 井澤修平
  • Organizer: 日本心理学会第74回大会
  • Place of Presentation: 大阪
• [Presentation] 社会的な刺激への注意と心理社会的ストレスに対する内分泌反応との関連 (2010)
  • Author(s): 木村健太
  • Organizer: 日本心理学会第74回大会
  • Place of Presentation: 大阪
• [Presentation] 過敏性腸症候群における心理社会的ストレス負荷時の認知的評価・不安・副腎皮質ホルモンの関連 (2010)
  • Author(s): 菅谷渚
  • Organizer: 日本心理学会第74回大会
  • Place of Presentation: 大阪