| Project/Area Number |
22740282
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biophysics/Chemical physics
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| Research Institution | High Energy Accelerator Research Organization |
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Principal Investigator |
YAMADA Norifumi 大学共同利用機関法人高エネルギー加速器研究機構, 物質構造科学研究所, 助教 (90425603)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生物物理 / 脂質 / 自己組織化 / 量子ビーム / 生体模倣膜 / 相分離 / リン脂質 / X線・粒子線 |
|---|
| Research Abstract |
A phospholipid is a main component of biomembranes, and spontaneously form bilayer structure in water. In this study, the effect of a phosphatidylethanolamine, a phospholipid related with a cell division, was investigated from the viewpoint of molecular shape. For this purpose, the phosphatidylethanolamine was mixed with a normal phospholipid as well as a phospholipid with short hydrocarbon chains which has an opposite molecular shape to phosphatidylethanolamine, and it was found that the membrane fusion was suppressed by the short-chain lipid. Also, the effect of short-chain phospholipid on the membrane structure was investigated, and it was found that the structural transformation caused by the short-chain phospholipid was induced by the phase separation between normal phospholipids and short-chain phospholipid.
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