| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
We have developed nickel-catalyzed oxidative direct biaryl couplings of heteroarenes with arylsilanes and arylboronic acids via C-H bond cleavage. The above catalysis enables the halogen-free construction of biaryl structures. Relevant new transformations of heteroarenes such as direct alkynylation, allylation, and alkylation were also achieved. Moreover, we succeeded in the copper-mediated dehydrogenative cross-biaryl couplings via two-fold C-H cleavage.
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