• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Asymmetric Synthesis of Chiral Organosilicon Compounds and Their Applications

Research Project

Project/Area Number 22750042
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Organic chemistry
Research InstitutionKyushu University

Principal Investigator

IGAWA Kazunobu  九州大学, 先導物質化学研究所, 助教 (80401529)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords有機元素化学 / 不斉合成 / キラルケイ素化合物 / 有機合成 / 有機ケイ素化合物 / ケイ素不斉 / キラルカルボン酸誘導体 / シラノール
Research Abstract

To efficiently approach non-racemic chiral organosilicon compounds, a novel reactive silane, which can react with nucleophiles in a stereospecific manner, and an oxidative cleavage reaction of C-Si bond with ozone have been developed. These new reactions allow to obtain a silicon congener of a-hydroxy carboxylic acid derivatives, which are difficult to obtain by other methods.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (32 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (25 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Directing Group-Controlled Hydrosilylation : Regioselective Functionalization of Alkyne2011

    • Author(s)
      Y. Kawasaki, Y. Ishikawa, K. Igawa, K. Tomooka
    • Journal Title

      J. Am. Chem. Soc

      Volume: Vol.133 Pages: 20712-20715

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Directing Group-Controlled Hydrosilylation : Regioselective Functionalization of Alkyne2011

    • Author(s)
      Yuuya Kawasaki; Youhei Ishikawa; Kazunobu Igawa; Katsuhiko Tomooka
    • Journal Title

      J.Am.Chem.Soc.

      Volume: 133 Issue: 51 Pages: 20712-20715

    • DOI

      10.1021/ja209553f

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic Chirality of (E)-5-Cyclononen-1-one and its Enolate2011

    • Author(s)
      K.Tomooka, T.Ezawa, H.Inone, K.Uehara, K.Igawa
    • Journal Title

      J.Am.Chem.Soc.

      Volume: 133 Pages: 1754-1756

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Addition-type Oxidation of Silylalkene Using Ozone : An Efficient Approach for Acyloin and Its Derivatives2011

    • Author(s)
      K.Igawa, Y.Kawasaki, K.Tomooka
    • Journal Title

      Chem.Lett.

      Volume: 40 Pages: 233-235

    • NAID

      10027815275

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Asymmetric Synthesis of Chiral Silacarboxylic Acids and Their Ester Derivatives2010

    • Author(s)
      K.Igawa, N.Kokan, K.Tomooka
    • Journal Title

      Angew.Chem.Int.Ed.

      Volume: 49 Pages: 728-731

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enantioselective Synthesis of Planar Chiral Organonitrogen Cycles2010

    • Author(s)
      K.Tomooka, K.Uehara, R.Nishikawa, M.Suzuki, K.Igawa
    • Journal Title

      J.Am.Chem.Soc.

      Volume: 132 Pages: 9232-9233

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ラルシリル基を導入したアルケンの不斉オゾン酸化2012

    • Author(s)
      井川和宣,西野浩輔,河崎悠也,友岡克彦
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶応義塾大学(横浜)
    • Year and Date
      2012-03-26
    • Related Report
      2011 Final Research Report
  • [Presentation] キラルシリル基を導入したアルケンの不斉オゾン酸化2012

    • Author(s)
      井川和宣, 西野浩輔, 河崎悠也, 友岡克彦
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      慶応義塾大学(横浜)
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] ケイ素を鍵とする新反応と新分子の開発2011

    • Author(s)
      井川和宣
    • Organizer
      徳島大学ジョイントセミナー(招待講演)
    • Place of Presentation
      徳島大学(徳島)
    • Year and Date
      2011-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] ケイ素を鍵とする新反応と新分子の開発2011

    • Author(s)
      井川和宣
    • Organizer
      徳島大学ジョイントセミナー
    • Place of Presentation
      徳島大学(徳島)(招待講演)
    • Year and Date
      2011-12-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Asymmetric Synthesis of Sila-carboxyli cAcid2011

    • Author(s)
      K. Igawa, N. Kokan, K. Tomooka
    • Organizer
      The 10th International Symposiumon Organic Reactions(招待講演)
    • Place of Presentation
      慶応義塾大学(横浜)
    • Year and Date
      2011-11-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Asymmetric Synthesis of Sila-carboxylic Acid2011

    • Author(s)
      Kazunobu Igawa; Naoto Kokan; Katsuhiko Tomooka
    • Organizer
      The 10th International Symposium on Organic Reactions
    • Place of Presentation
      慶応義塾大学(横浜)(招待講演)
    • Year and Date
      2011-11-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Workshop : Advanced Version of WOCJC2011

    • Author(s)
      K. Igawa
    • Organizer
      Enantioselective Synthesis of Chiral Silanol Using Asymmetric Nucleophilic Substitution Reaction of Achiral Dialkoxysilane(招待講演)
    • Place of Presentation
      東京工業大学(東京)
    • Year and Date
      2011-11-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Enantioselective Synthesis of Chiral Silanol Using Asymmetric Nucleophilic Substitution Reaction of Achiral Dialkoxysilane2011

    • Author(s)
      Kazunobu Igawa
    • Organizer
      Senior Workshop : Advanced Version of WOCJC
    • Place of Presentation
      慶応義塾大学(横浜)(招待講演)
    • Year and Date
      2011-11-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Enantioselective Synthesis of Si-stereogenic Silanol and Its Transformation2011

    • Author(s)
      Kazunobu Igawa; Junko Takada; Naoto Kokan; Tomohiro Shimono; Katsuhiko Tomooka
    • Organizer
      The 7th International Symposium on Integrated Synthesis
    • Place of Presentation
      シーサイドホテル舞子ビラ神戸(神戸)
    • Year and Date
      2011-10-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] シリル基の置換基効果による反応制御とその応用,京都大学GCOEプログラム「物質科学の新基盤構築と次世代育成国際拠点」2011

    • Author(s)
      井川和宣
    • Organizer
      第5回GCOE有機若手ワークショップ(招待講演)
    • Place of Presentation
      京都大学(京都)
    • Year and Date
      2011-09-13
    • Related Report
      2011 Final Research Report
  • [Presentation] シリル基の置換基効果による反応制御とその応用2011

    • Author(s)
      井川和宣
    • Organizer
      京都大学GCOEプログラム「物質科学の新基盤構築と次世代育成国際拠点」第5回GCOE有機若手ワークショップ
    • Place of Presentation
      京都大学(京都)(招待講演)
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 不斉ケイ素補助基を用いたジアステレオ選択的オゾン酸化反応の開発,有機合成化学協会九州山口支部2011

    • Author(s)
      井川和宣,河崎悠也,西野浩輔,友岡克彦
    • Organizer
      第23回若手研究者のためのセミナー
    • Place of Presentation
      九州大学(福岡)
    • Year and Date
      2011-08-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 不斉ケイ素補助基を用いたジアステレオ選択的オゾン酸化反応の開発2011

    • Author(s)
      井川和宣, 河崎悠也, 西野浩輔, 友岡克彦
    • Organizer
      有機合成化学協会九州山口支部第23回若手研究者のためのセミナー
    • Place of Presentation
      九州大学(福岡)
    • Year and Date
      2011-08-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 不斉補助基法によるジアステレオ選択的オゾン酸化の開発2011

    • Author(s)
      井川和宣,河崎悠也,西野浩輔,友岡克彦
    • Organizer
      第48回化学関連支部合同九州大会
    • Place of Presentation
      北九州国際会議場(北九州)
    • Year and Date
      2011-07-08
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] シラカルボン酸エステルの合成とその反応2011

    • Author(s)
      井川和宣,河崎悠也,古閑直人,友岡克彦
    • Organizer
      日本化学会第91春季年会
    • Place of Presentation
      神奈川大学(横浜)
    • Year and Date
      2011-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] ジアステレオ選択的付加型オゾン酸化:アシロインの不斉合成への展開2011

    • Author(s)
      井川和宣, 河崎悠也, 西野浩輔, 古閑直人, 友岡克彦
    • Organizer
      日本化学会 第91春季年会
    • Place of Presentation
      神奈川大学(神奈川県)
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] シラカルボン酸エステルの合成とその反応2011

    • Author(s)
      井川和宣, 河崎悠也, 古閑直人, 友岡克彦
    • Organizer
      日本化学会 第91春季年会
    • Place of Presentation
      神奈川大学(神奈川県)
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 非対称アルキンの位置選択的ヒドロシリル化2011

    • Author(s)
      河崎悠也, 石川洋平, 井川和宣, 友岡克彦
    • Organizer
      日本化学会 第91春季年会
    • Place of Presentation
      神奈川大学(神奈川県)
    • Year and Date
      2011-03-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] Asymmetric Synthesis of Si-stereogenic Compounds based on Chiral Silanol2011

    • Author(s)
      K. Igawa, J. Takada, N. Kokan, T. Shimono, K. Tomooka
    • Organizer
      The 1st International Conference on MEXT Project of Integrated Research on Chemical Synthesis
    • Place of Presentation
      北海道大学触媒センター(札幌)
    • Related Report
      2011 Final Research Report
  • [Presentation] Asymmetric Synthesis of Si-stereogeuic Compounds based on Chiral Silanol2011

    • Author(s)
      K.Igawa, J.Takada, N.Kokan, T.Shimono, K.Tomooka
    • Organizer
      The 1st International Conference on MEXT Project of Integrated Research on Chemical Synthesis
    • Place of Presentation
      北海道大学触媒センター(北海道)
    • Related Report
      2010 Annual Research Report
  • [Presentation] キラル有機ケイ素化合物の不斉合成2010

    • Author(s)
      井川和宣
    • Organizer
      有機合成化学協会・九州山口支部有機合成化学秋期講演会(招待講演)
    • Place of Presentation
      広島大学(広島)
    • Year and Date
      2010-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] キラル有機ケイ素化合物の不斉合成2010

    • Author(s)
      井川和宣
    • Organizer
      有機合成化学協会・九州山口支部 有機合成化学秋期講演会
    • Place of Presentation
      広島大学(広島県)
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Asymmetric Synthesis of Chiral Silanol and Its Transformation2010

    • Author(s)
      K. Igawa, A. Nakazaki, J. Takada, N. Kokan, T. Shimono, J. Usuki, K. Tomooka
    • Organizer
      Asymmetric Synthesis of Chiral Silanol and Its Transformation
    • Place of Presentation
      Taiwan
    • Year and Date
      2010-11-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Asymmetric Synthesis of Chiral Silanol and Its Transformation2010

    • Author(s)
      K.Igawa, A.Nakazaki, J.Takada, N.Kokan, T.Shimono, J.Usuki, K.Tomooka
    • Organizer
      5th International Conference on Cutting-Edge Organic Chemistry in Asia (ICCEOCA-5)
    • Place of Presentation
      Hsinchu, Taiwan
    • Year and Date
      2010-11-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 付加型オゾン酸化によるアルケンの高度酸素官能基化2010

    • Author(s)
      河崎悠也, 崎田享平, 村上正徳, 井川和宣, 友岡克彦
    • Organizer
      第97回有機合成シンポジウム
    • Place of Presentation
      慶応義塾大学薬学部(東京都)
    • Year and Date
      2010-06-19
    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] シロキサン類、シラノール、及びシラン類、並びにその製造方法

    • Inventor(s)
      友岡克彦,井川和宣,高田純子
    • Industrial Property Rights Holder
      友岡克彦,井川和宣,高田純子
    • Related Report
      2011 Final Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi