| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
Biotinylation reaction from archaeon Sulfolobus tokodaii has a unique characteristic that the biotin ligase forms a stable complex with its biotinylated substrate protein. In the present work, by using this unique biotinylation reaction, we attempted to construct the system that enables the regulation of the functions of the target proteins in living cells. As a result of the study , we have succeeded in the regulation of localization of a target protein in living cells.
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