| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
I developed methods on single-molecule tunnel-current identification with STM and nanogap-electrode. By using these methods, the electron-conductance values were determined for perfect-matched and miss-matched DNA duplexes, and single DNA/ RNA nucleotides, and post-transcriptional modified-nucleotides. Based on these relative conductance values, the sequence of oligonucleotides was successfully determined. In addition, methodologies, for a molecule-control by using nanopore, molecule-recognition by using photonic waveguide, and a construction of DNA-based nanostructures, were also developed.
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