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Development of multielement measurement method for exhaustive study of essential elements in cells

Research Project

Project/Area Number 22750080
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Analytical chemistry
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

INAGAKI Kazumi  独立行政法人産業技術総合研究所, 計測標準研究部門, 研究室付 (50356490)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords細胞 / 誘導結合プラズマ質量分析 / 多元素分析 / 分析科学 / 細胞・組織
Research Abstract

We have developed a new analytical system based on plasma mass spectrometry to realize a single cell analysis of trace elements. The system is constructed of inductively coupled plasma mass spectrometry and its new sample introduction interface that can directly introduce cells into the plasma. The system can get a snap shot of the moment of the decomposition of a cell in the plasma, and can measure multielement in the cell at a time. In the application for multielement analysis of a single yeast cell, Mg, P, and Zn can successfully be measured in single yeast cells.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (12 results)

All 2012 2011 2010

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (10 results)

  • [Journal Article] Development of Salt-Tolerance Interface for an High Performance Liquid Chromatography/Inductively Coupled Plasma Mass Spectrometry System and Its Application to Accurate Quantification of DNA Samples2012

    • Author(s)
      Y.Takasaki, S.Sakagawa, K.Inagaki, S.Fujii, A.Sabarudin, T.Umemura, H.Haraguchi
    • Journal Title

      Anal.Chim.Acta

      Volume: 713 Pages: 23-29

    • DOI

      10.1016/j.aca.2011.11.039

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multielement Analysis of Micro-volume Biological Samples by ICP-MS with Highly Efficient Sample Introduction System2011

    • Author(s)
      Y.Takasaki, K.Inagaki, A.Sabarudin, S.Fuji, D.Iwahata, A.Takatsu, K.Chiba, T.Umemura
    • Journal Title

      Talanta

      Volume: 87 Pages: 24-29

    • DOI

      10.1016/j.talanta.2011.09.022

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 単一酵母細胞中微量元素の高感度多元素分析2012

    • Author(s)
      稲垣和三
    • Organizer
      日本薬学会132年会
    • Place of Presentation
      北海道、北海道大学
    • Year and Date
      2012-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] 単一酵母細胞中微量元素の高感度多元素分析2012

    • Author(s)
      稲垣和三
    • Organizer
      日本薬学会132年会
    • Place of Presentation
      北海道、北海道大学(招待講演)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] High sensitive analysis of trace element in Yeast Cell by Time-resolved ICP-MS with High Efficiency Cell Introduction Device2011

    • Author(s)
      稲垣和三
    • Organizer
      78th Annual Meeting of Korean Society of Food Science and Technology
    • Place of Presentation
      韓国, Daegu、Exhibition Convention Center
    • Year and Date
      2011-06-08
    • Related Report
      2011 Final Research Report
  • [Presentation] High sensitive analysis of trace element in Yeast Cell by Time-resolved ICP-MS with High Efficiency Cell Introduction Device2011

    • Author(s)
      稲垣和三
    • Organizer
      78th Annual Meeting of Korean Society of Food Science and Technology
    • Place of Presentation
      韓国,Daegu、Exhibition Convention Center(招待講演)
    • Year and Date
      2011-06-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Multielement analysis of yeast cell by time-resolved ICP-MS with high efficiency cell introduction device2011

    • Author(s)
      稲垣和三
    • Organizer
      ICAS2011
    • Place of Presentation
      京都府、国立京都国際会館
    • Year and Date
      2011-05-25
    • Related Report
      2011 Final Research Report
  • [Presentation] MULTIELEMENT ANALYSIS OF YEAST CELL BY TIME-RESOLVED ICP-MS WITH HIGH EFFICIENCY2011

    • Author(s)
      稲垣和三
    • Organizer
      ICAS2011
    • Place of Presentation
      京都府、国立京都国際会館
    • Year and Date
      2011-05-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Time-resolved ICP-MS Measurement for Multielement Analysis of Single-cell2011

    • Author(s)
      稲垣和三、藤井紳一郎、大畑昌輝、高崎裕加、梅村知也、高津章子、千葉光一
    • Organizer
      2011 European Winter Conference on Plasma Spectrochemistry
    • Place of Presentation
      Zaragoza, Spain
    • Year and Date
      2011-02-03
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Development of High Performance Concentric Nebulizer for ICP-OES and ICP-MS2011

    • Author(s)
      稲垣和三、藤井紳一郎、高津章子、千葉光一
    • Organizer
      2011 European Winter Conference on Plasma Spectrochemistry
    • Place of Presentation
      Zaragoza, Spain
    • Year and Date
      2011-02-03
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 細胞直接導入/ICP-MSによる酵母細胞の多元素分析2010

    • Author(s)
      稲垣和三、藤井紳一郎、大畑昌輝、高崎裕加、梅村知也、高津章子、千葉光一
    • Organizer
      第2回メタロミクス研究フォーラム
    • Place of Presentation
      京都府、京都薬科大学
    • Year and Date
      2010-11-03
    • Related Report
      2011 Final Research Report
  • [Presentation] 細胞直接導入/ICP-MS による酵母細胞の多元素分析2010

    • Author(s)
      稲垣和三、藤井紳一郎、大畑昌輝、高崎裕加、梅村知也、高津章子、千葉光一
    • Organizer
      第2回メタロミクス研究フォーラム
    • Place of Presentation
      京都
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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