| Project/Area Number |
22750089
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Nagoya Institute of Technology |
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Principal Investigator |
NAKAMURA Shuichi 名古屋工業大学, 大学院・工学研究科, 准教授 (20335087)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | 不斉合成 / 反応 / 有機合成化学 / 生理活性物質 / 環境調和型反応 / 不斉触媒 |
|---|
| Research Abstract |
In order to develop the synthesis of chiral compounds, we designed novel organocatalysts having a coordinative heteroaryl group in their structures. Although enantioselective aldol reaction to ketone is generally difficult, the reaction using our novel organocatalysts afforded good results. Especially, biologically active flustraminol and AG-041R derivatives can be prepared by using the organocatalysts. Furthermore, organocatalyst could be readily reusable without significant loss of catalytic activity or enantioselectivity.
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