| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
We have developed a flow-microreactor approach to protecting-group free synthesis. In this research, we have found that the use of flow microreactor systems could be effective method for(2)generation and reactions of aryllithiums bearing electrophilic functional groups such as alkoxycarbonyl, cyano and nitro groups that such transformations are very difficult or impossible with a conventional macrobatch system(2)generation and reactions of aryllithiums bearing ketone carbonyl groups that such transformations are impossible with a conventional macrobatch system, and(3)the formal synthesis of Malachite green.
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