Development of New Acylation Reactions via Aromatic Carbon-Hydrogen Bond Cleavaege by Transition Metal Catalysts
| Project/Area Number |
22750096
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Keio University |
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Principal Investigator |
KOCHI Takuya 慶應義塾大学, 理工学部, 講師 (70396779)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ルテニウム触媒 / 炭素-水素結合切断 / 炭素-炭素結合形成 / アシル化 / ピリジン誘導体 / キレート形成 / 酸塩化物 / カルボニル化合物 / 炭素-水素結合官能基化 / エノン / ジアリールケトン |
|---|
| Research Abstract |
Catalytic functionalization via cleavage of unreactive carbon-hydrogen bonds by transition metal complexes has been widely studied in recent years. As a new method in this class of reactions, we developed a reaction for catalytic introduction of acyl groups using acyl chlorides. When arylpyridines are reacted with acyl chlorides such as benzoyl chlorides and alkenoyl chlorides, ortho-selective acylation proceeded to give benzophenone and enone derivatives.
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Report
(3 results)
Research Products
(24 results)
