| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Mechanistic analysis for structural formation of polyplex micelles as gene delivery system was demonstrated. Main object of this work was placed on understanding principle factors to determine the folding number of plasmid DNA (pDNA) within the polyplex micelles, where pDNA is packaged by highly regulated folding manner, namely quantized folding scheme. The research performed on a basis of kinetic analysis approved that folding process of pDNA is consistently described in the same way as kinetics of polymer crystallization. The deeper understanding on the structure formation of polyplex micelles enables secure molecular design for promoting effective gene delivery carriers.
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