Development of photofunctional molecules that generate calcium signals
| Project/Area Number |
22750143
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 光分解 / ケージド化合物 / カルシウムシグナル / 光誘起電子移動 / カルシウムシグナリング / 光分解反応 / 光化学 / 細胞イメージング / カルシウムイオン / 光神経科学 |
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| Research Abstract |
In this research we aimed to improve photochemical efficiency of the molecules that are able to release calcium ion by photo excitation (caged calcium). The quantum yield for photolysis of new BAPTA-based caged calcium is found to low due to forming charge transfer complex in the ground state. On the other hands, we successfully developed novel photolabile protecting groups for caged calcium whose quantum yield of photolysis was more than 0.5.
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Report
(4 results)
Research Products
(54 results)
