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Development of photofunctional molecules that generate calcium signals

Research Project

Project/Area Number 22750143
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Chemistry related to living body
Research InstitutionUniversity of Tsukuba

Principal Investigator

MOMOTAKE Atsuya  筑波大学, 数理物質系, 講師 (70375369)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords光分解 / ケージド化合物 / カルシウムシグナル / 光誘起電子移動 / カルシウムシグナリング / 光分解反応 / 光化学 / 細胞イメージング / カルシウムイオン / 光神経科学
Research Abstract

In this research we aimed to improve photochemical efficiency of the molecules that are able to release calcium ion by photo excitation (caged calcium). The quantum yield for photolysis of new BAPTA-based caged calcium is found to low due to forming charge transfer complex in the ground state. On the other hands, we successfully developed novel photolabile protecting groups for caged calcium whose quantum yield of photolysis was more than 0.5.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (54 results)

All 2013 2012 2011 2010

All Journal Article (29 results) (of which Peer Reviewed: 29 results) Presentation (25 results)

  • [Journal Article] Photochemistry of arylacetylenyl-substituted stilbenes. Journal of Photochemistry and Photobiology2013

    • Author(s)
      Suzuki, M.; Momotake, A.; Kanna, Y.; Nishimura, Y.; Hirota, K.; Morihashi, K.; Arai, T.
    • Journal Title

      A: Chemistry

      Volume: 252 Pages: 203-210

    • DOI

      10.1016/j.jphotochem.2012.11.019

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Excited state intramolecular hydrogen atom transfer of phenylethynyl-substituted 2'-hydroxychalcones2013

    • Author(s)
      Tasaki, S.; Momotake, A.; Kanna, Y.; Arai, T
    • Journal Title

      Research on Chemical Intermediates

      Volume: 39 Issue: 1 Pages: 61-72

    • DOI

      10.1007/s11164-012-0632-8

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extremely efficient photoisomerization of water-soluble diphenylbutadiene dendrimers2012

    • Author(s)
      Miura, Y.; Momotake, A.; Kanna, Y.; Nishimura, Y.; Arai, T
    • Journal Title

      Dyes and Pigments

      Volume: 92 Pages: 802-806

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-Acyl-N-carboxymethyl-2-nitroaniline and its analogues: a new class of water-soluble photolabile precursor of carboxylic acids2012

    • Author(s)
      Honda, T.; Momotake, A.; Arai, T
    • Journal Title

      Photochem. Photobiol. Sci

      Volume: 11 Issue: 3 Pages: 493-496

    • DOI

      10.1039/c2pp05322e

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Environmental polarity estimation in living cells by use of quinoxaline-based full-colored solvatochromic fluorophore PQX and its derivatives2012

    • Author(s)
      Kudo, et al
    • Journal Title

      Photochem Photobiol Sci

      Volume: 11 Issue: 4 Pages: 674-678

    • DOI

      10.1039/c2pp05337c

    • Related Report
      2012 Annual Research Report 2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 2-(N-acyl-N-carboxymethylamino)-1-nitrodibenzo[b,d]thiophene: a new class of caging group for environmental selective photorelease of carboxylic acid.2012

    • Author(s)
      Tanaka, Y.; Momotake, A.; Arai, T
    • Journal Title

      Chemistry Letters 2012

      Volume: 41 Issue: 6 Pages: 642-643

    • DOI

      10.1246/cl.2012.642

    • NAID

      130004426596

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Polarity-dependent photophysical properties of hemicyanine dyes and their application in 2-photon microscopy biological imaging.2012

    • Author(s)
      Kimura, Y., Momotake, A., Takahashi, N., Kasai, H. & Arai, T.
    • Journal Title

      Chemistry Letters

      Volume: 41 Issue: 5 Pages: 528-530

    • DOI

      10.1246/cl.2012.528

    • NAID

      10030619751

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Self-assembly of a poly(glutamate) dendrimer: solventdependent expression of molecular chirality and a [2 + 2] photocrosslinking reaction2012

    • Author(s)
      Ikeda, M.; Momotake, A.; Kanna, Y.; Shimotori, K.; Arai, T.
    • Journal Title

      Photochemical & Photobiological Sciences

      Volume: 11 Issue: 10 Pages: 1524-1527

    • DOI

      10.1039/c2pp25221j

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic localized calcium transients directly probe signalling mechanisms in skeletal muscle2012

    • Author(s)
      Figueroa, L.
    • Journal Title

      Journal of Physiology

      Volume: 590 Issue: 6 Pages: 1389-1411

    • DOI

      10.1113/jphysiol.2011.225854

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The use of dendrimers as high-performance shells for round-trip energy transfer: efficient trans-cis photoisomerization from an excited triplet state produced within a dendrimer shell.2011

    • Author(s)
      Miura, Y.; Momotake, A.; Takeuchi, K.; Arai, T.
    • Journal Title

      Photochem. Photobiol. Sci

      Volume: 10 Issue: 1 Pages: 116-122

    • DOI

      10.1039/c0pp00272k

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Singlet molecular oxygen generation by water-soluble phthalocyanine dendrimers with different aggregation behavior2011

    • Author(s)
      Nishida, M.; Horiuchi, H.; Momotake, A.; Nishimura, Y.; Hiratsuka, H.; Arai, T
    • Journal Title

      Porphyrins and Phthalocyanines

      Volume: 15 Pages: 47-53

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a quinoxaline-based fluorescent probe for quantitative estimation of protein binding site polarity2011

    • Author(s)
      Kudo, K.; Momotake, A.; Kanna, Y.; Nishimura, Y.; Arai, T.
    • Journal Title

      Chem. Commun

      Volume: 47 Issue: 13 Pages: 3867-3869

    • DOI

      10.1039/c1cc10183h

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Energy Transfer and trans-cis Isomerization in Dendrimer Aggregates2011

    • Author(s)
      Miura. Y.; Momotake, A.; Kanna, Y.; Nishimura, Y.; Arai, T.
    • Journal Title

      Bull. Chem. Soc. Jpn

      Volume: 84 Pages: 363-365

    • NAID

      10028046713

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extremely efficient and long lifetime fluorescence of cis-stilbene contained in a rigid dendrimer.2011

    • Author(s)
      Tabuchi, M.; Momotake, A.; Kanna, Y.; Nishimura, Y.; Arai, T
    • Journal Title

      Photochemical & Photobiological Sciences 2011

      Volume: 10 Issue: 10 Pages: 1521-1523

    • DOI

      10.1039/c1pp05126a

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Observation of Anthracene Excimer Fluorescence at Very Low Concentrations Utilizing Dendritic Structures, J. Photochem2011

    • Author(s)
      Akatsuka R.; Momotake, A.; Shinohara, Y.; Kanna, Y.; Sato, T.; Moriyama, M.; Takahashi, K.; Nishimura, Y.; Arai, T
    • Journal Title

      Photbiol. A: Chem.

      Volume: 223 Pages: 1-5

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Unusually efficient trans-to-cis photoisomerization of diphenylbutadiene dendrimers in water2011

    • Author(s)
      Miura. Y.; Momotake, A.; Kanna, Y.; Nishimura, Y.; Arai, T.
    • Journal Title

      Photochem. Photobiol. Sci

      Volume: 10 Issue: 10 Pages: 1524-1526

    • DOI

      10.1039/c1pp05212h

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Spatial distributions of GABA receptors and local inhibition of Ca^<2+> transients studied with GABA uncaging in the dendrites of CA1 pyramidal neurons2011

    • Author(s)
      Yuya Kanemoto, Masanori Matsuzaki, Susumu Morita, Tatsuya Hayama, Jun Noguchi, Naoko Senda, Atsuya Momotake, Tatsuo Arai, Haruo Kasai
    • Journal Title

      PLoS One

      Volume: 6 Issue: 7 Pages: e22652-e22652

    • DOI

      10.1371/journal.pone.0022652

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Energy Transfer and trans-cis Isomerization in Dendrimer Aggregates2011

    • Author(s)
      Miura. Y.
    • Journal Title

      Bull.Chem.Soc.Jpn.

      Volume: 84 Issue: 4 Pages: 363-365

    • DOI

      10.1246/bcsj.20100318

    • NAID

      130004152891

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Observation of Anthracene Excimer Fluorescence at Very Low Concentrations Utilizing Dendritic Structures2011

    • Author(s)
      Akatsuka R.
    • Journal Title

      J.Photochem.Phothiol.A : Chem.

      Volume: 223 Issue: 1 Pages: 1-5

    • DOI

      10.1016/j.jphotochem.2011.07.008

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Singlet molecular oxygen generation by water-soluble phthalocyanine dendrimers with different aggregation behavior.2011

    • Author(s)
      Nishida, M.
    • Journal Title

      Journal of Porphyrins and Phthalocyanines

      Volume: 15 Pages: 47-53

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The use of dendrimers as high-performance shells for round-trip energy transfer : efficient trans-cis photoisomerization from an excited triplet state produced within a dendrimer shell.2011

    • Author(s)
      Miura, Y.
    • Journal Title

      Photochemical & Photobiological Sciences

      Volume: 10 Pages: 116-122

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a quinoxaline-based fluorescent probe for quantitative estimation of protein binding site polarity.2011

    • Author(s)
      Kudo, K.
    • Journal Title

      Chemical Communications

      Volume: 47 Pages: 3867-3869

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 1-Acyl-5-methoxy-8-nitro-1,2-dihydroquinoline: a biologically useful photolabile precursor of carboxylic acids2010

    • Author(s)
      Obi, N.; Momotake, A.; Kanemoto, Y.; Matsuzaki, M.; Kasai, H.; Arai, T
    • Journal Title

      Tetrahedron Lett

      Volume: 51 Issue: 13 Pages: 1642-1647

    • DOI

      10.1016/j.tetlet.2009.12.081

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescence enhancement in 7-hydroxyquinoline analogs by methyl substitution and their spectroscopic characteristics in aqueous solution2010

    • Author(s)
      Senda, N.; Momotake, A.; Arai, T
    • Journal Title

      Bull. Chem. Soc. Jpn

      Volume: 83 Issue: 10 Pages: 1272-1274

    • DOI

      10.1246/bcsj.20100119

    • NAID

      130004058976

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Substituent effect of 7-hydroxy-1-methylquinolinium derivatives: a photochemical approach to development of new fluorescent pH indicator2010

    • Author(s)
      Senda, N.; Momotake, A.; Arai, T
    • Journal Title

      Heterocycles

      Volume: 81 Issue: 10 Pages: 2343-2350

    • DOI

      10.3987/com-10-11996

    • NAID

      40017284225

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photochemistry of Linear-Shaped Phenylacetylenyl- and (Phenylacetylenyl)phenylacetylenyl-Substituted Aromatic Enediynes2010

    • Author(s)
      Sugiyama, Y.; Shinohara, Y.; Momotake, A.; Takahashi, K.; Kanna, Y.; Nishimura,Y.; Arai, T.
    • Journal Title

      J. Phys. Chem. A

      Volume: 114 Issue: 41 Pages: 10929-10935

    • DOI

      10.1021/jp1054827

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photochemistry of Linear-Shaped Phenylacetylenyl- and (Phenylacetylenyl)phenylacetylenyl-Substituted Aromatic Enediynes.2010

    • Author(s)
      Sugiyama, Y.
    • Journal Title

      Journal of Physical Chemistry A

      Volume: 114 Pages: 10929-10935

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Substituent effect of 7-hydroxy-1-methylquinolinium derivatives : a photochemical approach to development of new fluorescent pH indicator.2010

    • Author(s)
      Senda, N.
    • Journal Title

      Heterocycles

      Volume: 81 Pages: 2343-2350

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescence enhancement in 7-hydroxyquinoline analogs by methyl substitution and their spectroscopic characteristics in aqueous solution.2010

    • Author(s)
      Senda, N.
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: 83 Pages: 1272-1274

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] ニトロベンゼン骨格を活用したケージド化合物合成への展開2012

    • Author(s)
      高橋洋平・百武篤也・新井達郎
    • Organizer
      光化学討論会
    • Place of Presentation
      東京工業大学大岡山キャンパス
    • Year and Date
      2012-09-14
    • Related Report
      2012 Final Research Report
  • [Presentation] 光誘起電子移動経由でカルボン酸を放出するケージド化合物の研究2012

    • Author(s)
      森山晴加・百武篤也・新井達郎
    • Organizer
      光化学討論会
    • Place of Presentation
      東京工業大学大岡山キャンパス
    • Year and Date
      2012-09-13
    • Related Report
      2012 Final Research Report
  • [Presentation] ニトロベンゼン骨格を有する新規ケージド化合物の合成と光化学的挙動2012

    • Author(s)
      高橋 洋平・百武篤也・新井 達郎
    • Organizer
      日本化学会第92 春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス・矢上キャンパス
    • Year and Date
      2012-03-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 新規アゾベンゼン色素の光化学的特性とそれらを利用した細胞膜イメージングへの応用に関する研究2012

    • Author(s)
      福嶋 瞬・百武篤也・新井 達郎
    • Organizer
      日本化学会第92 春季年会
    • Place of Presentation
      慶應義塾大学日吉キャンパス・矢上キャンパス
    • Year and Date
      2012-03-26
    • Related Report
      2012 Final Research Report
  • [Presentation] ドナー・アクセプター型アゾベンゼンの光化学的挙動とイオンセンシングに関する研究2012

    • Author(s)
      福嶋瞬・百武篤也・新井達郎
    • Organizer
      光化学討論会
    • Place of Presentation
      東京工業大学大岡山キャンパス
    • Related Report
      2012 Final Research Report
  • [Presentation] 光誘起電子移動経由でカルボン酸を放出するケージド化合物の研究2012

    • Author(s)
      森山晴加
    • Organizer
      2012光化学討論会
    • Place of Presentation
      東京工業大大岡山キャンパス
    • Related Report
      2012 Annual Research Report
  • [Presentation] ニトロベンゼン骨格を活用したケージド化合物合成への展開2012

    • Author(s)
      高橋洋平
    • Organizer
      2012光化学討論会
    • Place of Presentation
      東京工業大大岡山キャンパス
    • Related Report
      2012 Annual Research Report
  • [Presentation] ドナー・アクセプター型アゾベンゼンの光化学的挙動とイオンセンシングに関する研究2012

    • Author(s)
      福嶋瞬
    • Organizer
      2012光化学討論会
    • Place of Presentation
      東京工業大大岡山キャンパス
    • Related Report
      2012 Annual Research Report
  • [Presentation] キノキサリン系蛍光プローブの開発と光化学的性質2011

    • Author(s)
      森山晴加
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2011-09-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] スチルベン骨格を中心に有するペプチドデンドリマーの光化学2011

    • Author(s)
      池田愛
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2011-09-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 光誘起電子移動を利用したケージドグルタミン酸の分解と高機能化に関する研究2011

    • Author(s)
      百武篤也
    • Organizer
      第5回バイオ関連化学シンポジウム
    • Place of Presentation
      つくば国際会議場
    • Year and Date
      2011-09-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] ポリグルタミン酸デンドリマーの光化学的特性2011

    • Author(s)
      池田愛・百武篤也・新井達郎
    • Organizer
      光化学討論会
    • Place of Presentation
      宮崎市河畔コンベンションエリア, 宮崎市
    • Year and Date
      2011-09-08
    • Related Report
      2012 Final Research Report
  • [Presentation] 光誘起電子移動反応を利用したケージドグルタミン酸の高性能化に関する研究2011

    • Author(s)
      森山晴加・百武篤也・西村賢宣・新井達郎
    • Organizer
      光化学討論会
    • Place of Presentation
      宮崎市河畔コンベンションエリア, 宮崎市
    • Year and Date
      2011-09-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Photochemical characteristics of poly (glutamate)dendrimers2011

    • Author(s)
      IKEDA, Megumi
    • Organizer
      2011光化学討論会
    • Place of Presentation
      宮崎市民プラザ
    • Year and Date
      2011-09-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] Study on photoinduced electron transfer reaction to induce highly efficient photolysis for cagedglutamates2011

    • Author(s)
      MORIYAMA, Haruka
    • Organizer
      2011光化学討論会
    • Place of Presentation
      宮崎市民プラザ
    • Year and Date
      2011-09-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] ニトロフルオレンまたはニトロジベンゾチオフェンを用いた新規ケージド化合物の合成とその光化学2011

    • Author(s)
      田中佑二・百武篤也・新井達郎
    • Organizer
      光化学討論会
    • Place of Presentation
      宮崎市河畔コンベンションエリア, 宮崎市
    • Year and Date
      2011-09-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Synthesis and substituent effect of caged compounds using nitroaniline skeleton2011

    • Author(s)
      HONDA, Takuya
    • Organizer
      2011光化学討論会
    • Place of Presentation
      宮崎市民プラザ
    • Year and Date
      2011-09-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] エステル表面官能基を有するベンジルエーテル型スチルベンデンドリマーの光化学的挙動と溶媒効果2011

    • Author(s)
      滝澤努・ 百武篤也 ・西村賢宣・新井達郎
    • Organizer
      光化学討論会
    • Place of Presentation
      宮崎市河畔コンベンションエリア, 宮崎市
    • Year and Date
      2011-09-06
    • Related Report
      2012 Final Research Report
  • [Presentation] ニトロアニリン骨格を用いたケージド化合物の合成と置換基効果2011

    • Author(s)
      本田拓也・百武篤也・新井達郎
    • Organizer
      光化学討論会
    • Place of Presentation
      宮崎市河畔コンベンションエリア, 宮崎市
    • Year and Date
      2011-09-06
    • Related Report
      2012 Final Research Report
  • [Presentation] Photochemical behavior and solvent effect of poly(benzyl ether)stilbene dendrimerswith ester surface functional groups2011

    • Author(s)
      TAKIZAWA, Tsutomu
    • Organizer
      2011光化学討論会
    • Place of Presentation
      宮崎市民プラザ
    • Year and Date
      2011-09-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 脂溶性ポリグルタミン酸デンドリマーの光化学的挙動2011

    • Author(s)
      池田愛
    • Organizer
      日本化学会第5回関東支部大会(2011)
    • Place of Presentation
      東京農工大学小金井キャンパス(東京都小金井市)
    • Year and Date
      2011-08-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] 2光子励起法を利用した細胞膜染色に用いる蛍光プローブの開発2010

    • Author(s)
      木村勇太
    • Organizer
      2010年光化学討論会
    • Place of Presentation
      千葉大学西千葉キャンパス
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] ベンジルエーテル型スチルベンデンドリマーの光化学的特性に及ぼす表面官能基の効果2010

    • Author(s)
      滝澤努
    • Organizer
      2010年光化学討論会
    • Place of Presentation
      千葉大学西千葉キャンパス
    • Year and Date
      2010-09-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] ニトロフルオレン骨格を用いた新規ケージング基の開発2010

    • Author(s)
      田中佑二
    • Organizer
      日本化学会第4回関東支部大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2010-08-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] C=C二重結合を有する蛍光性キノキサリン-ピロール連結化合物のソルバトクロミック特性2010

    • Author(s)
      工藤健太郎
    • Organizer
      日本化学会第4回関東支部大会
    • Place of Presentation
      筑波大学
    • Year and Date
      2010-08-30
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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