Nanoarraying of Proteins on DNA Nanostructures and Single-Molecule Observation of Enzymes
| Project/Area Number |
22750144
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kansai University (2011)
The University of Tokyo (2010) |
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Principal Investigator |
KUZUYA Akinori 関西大学, 化学生命工学部, 准教授 (00456154)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | DNA / DNAナノ構造体 / 単分子解析 / ナノ構造体 / DNAナノテクノロジー / DNAオリガミ / 酵素 / 一分子観察 / ナノデバイス / 生体分子 / 酵素反応 / ナノバイオ / 単分子検出 |
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| Research Abstract |
We have developed versatile sensing systems for a variety of chemical and biological targets at molecular resolution. We have designed functional nanomechanical DNA origami devices that can be used as "single-molecule beacons", which consist of two levers approximately 170 nm long connected at a fulcrum. Various single-molecule inorganic/organic targets ranging from metal ions to proteins can be visually detected on AFM by a shape transition of the origami devices.
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Report
(3 results)
Research Products
(24 results)
