| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
In this study, we aimed to develop highly-sensitive labeling agents by incorporating fluorophores into DNA. We developed artificial base pairs by incorporating cyclohexane derivatives between a fluorophore and nucleobases. As a result, quantum yields of fluorophores such as pyrene and perylenediimide were drastically enhanced. In addition, we demonstrated that the quantum yield of FITC was also improved by incorporating cyclohexane derivatives.
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