Functional elucidation of the AMP metabolic pathway in Archaea
| Project/Area Number |
22750150
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kyoto University |
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Principal Investigator |
SATO Takaaki 京都大学, 大学院・工学研究科, 助教 (60571411)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | アーキア / 微生物代謝 / ペントース代謝 / AMP / バイオテクノロジー / 核酸代謝 / ヌクレオシド代謝 |
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| Research Abstract |
In order to elucidate the function of an archaeal AMP metabolic pathway, biochemical and structural analyses of enzymes composing the pathway were performed. The results revealed that the AMP metabolic pathway is dramatically activated by AMP and ADP and degrades not only AMP but also CMP and UMP. These results suggested that the physiological functions of this pathway may be involved in the assimilation of extracellular nucleotides and/or in salvaging energy from AMP/CMP/UMP when intracellular energy levels are low, and AMP/ADP concentrations are relatively high.
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Report
(4 results)
Research Products
(19 results)
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[Journal Article] Dynamic, ligand-dependent conforma-tional change triggers the reaction of ribose-1, 5-bisphosphate isomerase from Thermococcus kodakarensis KOD12012
Author(s)
Akira Nakamura, Masahiro Fujihashi, Riku Aono, Takaaki Sato, Yosuke Nishiba, Shosuke Yoshida, Ayumu Yano, Haruyuki Atomi, Tadayuki Imanaka, and Kunio Miki
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Journal Title
J. Biol. Chem
Volume: (in press)
Issue: 25
Pages: 20784-20796
DOI
Related Report
Peer Reviewed
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[Presentation] Dynamic, ligand-dependent conformational change triggers the reaction of ribose-1,5-bisphosphate isomerase from Thermococcus kodakarensis2012
Author(s)
Takaaki Sato, Akira Nakamura, Riku Aono, Masahiro Fujihashi, Yosuke Nishiba, Shosuke Yoshida, Ayumu Yano, Tadayuki Imanaka, Kunio Miki and Haruyuki Atomi
Organizer
Extremophiles 2012 (国際学会)
Place of Presentation
Seville, Spain
Year and Date
2012-09-10
Related Report
Int'l Joint Research
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[Presentation] Novel enzymes involved in pentose metabolism in the Archaea2011
Author(s)
Takaaki Sato, Riku Aono, Akira Nakamura, Yuichi Nishitani, Masahiro Fujihashi, Ayumu Yano, Shosuke Yoshida, Tadayuki Imanaka, Kunio Miki, and Haruyuki Atomi
Organizer
Japanese-German Workshop on Enzyme Technology
Place of Presentation
Toyama, Japan
Year and Date
2011-09-14
Related Report
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