| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
In order to elucidate the function of an archaeal AMP metabolic pathway, biochemical and structural analyses of enzymes composing the pathway were performed. The results revealed that the AMP metabolic pathway is dramatically activated by AMP and ADP and degrades not only AMP but also CMP and UMP. These results suggested that the physiological functions of this pathway may be involved in the assimilation of extracellular nucleotides and/or in salvaging energy from AMP/CMP/UMP when intracellular energy levels are low, and AMP/ADP concentrations are relatively high.
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