Development of the recognition motif of DNA oxidation and its application to comprehensive analysis of DNA mutation.
| Project/Area Number |
22750154
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
KOBORI Akio 京都工芸繊維大学, 工芸科学研究科, 准教授 (00397605)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 酸化損傷塩基 / DNA / 変異原性 |
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| Research Abstract |
This project was consisted of two major parts.
Part 1 : To elucidate the effects of 8-oxo-7, 8-dihydroguanine on nucleotide diversity, we constructed of 8-oxoG motif using small organic molecules. Part 2 : Probing the requirements for catalysis in 8-oxoG repair enzymes.
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Report
(3 results)
Research Products
(42 results)
