| Project/Area Number |
22750156
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemistry related to living body
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| Research Institution | Nara Institute of Science and Technology |
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Principal Investigator |
MATSUO Takashi 奈良先端科学技術大学院大学, 物質創成科学研究科, 准教授 (50432521)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | インターエレメント / タンパク質デザイン / 白金錯体 / 触媒反応 / 有機金属 |
|---|
| Research Abstract |
Some artificial metalloproteins were successfully constructed from the aspects of "fashions of metal coordination","inter-element principal(interactions between elements)" and "structural characteristics of proteins". An organometallic artificial protein with a C-coordinated metal center was prepared through inhibition mechanism of serine proteases. Furthermore, we successfully develop a protein structure-based switching system of emission property of a metal complex attached onto the surface the protein. We also found autoreduction of a copper ion with S-coordination, which was constructed at the active site of a chemically modified subtilisin.
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