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Synthetic Study of A Heterocyclic Molecular Motor Toward DNA Conformational Change

Research Project

Project/Area Number 22750159
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Chemistry related to living body
Research InstitutionToho University

Principal Investigator

KUWAHARA Shunsuke  東邦大学, 理学部, 講師 (40359550)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords分子マシン / 分子モーター / DNA / 光スイッチ / 光異性化
Research Abstract

We have designed a new heterocyclic molecular motor 2, which would intercalate in the DNA and induce conformational change of the DNA structure. Heterocyclic molecular motors (±)-trans-8and (±)-cis-8were prepared by the McMurry coupling and Buchwald-Hartwig reaction of heterocyclic ketone (±)-7d. The relative stereochemistry of (±)-trans-8and (±)-cis-8was determined as (2R*,2'R*)-(P*,P*) by X- ray crystallography. CD spectral titration experiments exhibit that significant conformational changes of B-DNA are not induced by (±)-trans-10and (±)-cis-10.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (11 results)

All 2013 2012 2011 Other

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (10 results)

  • [Journal Article] Synthesis of peptide-conjugated light-driven molecular motors and evaluation of their DNA-binding properties2013

    • Author(s)
      Fumi Nagatsugi, Yusuke Takahashi, Maiko Kobayashi, Shunsuke Kuwahara, Shuhei Kusano, Tomoko Chikuni, Shinya Hagihara and Nobuyuki Harada
    • Journal Title

      Mol. Bio Syst.

      Volume: 9 Issue: 5 Pages: 969-973

    • DOI

      10.1039/c2mb25520k

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Presentation] DNAの構造制御を目指した複素環型分子モーターの合成研究2013

    • Author(s)
      野口敏明, 幅田揚一, 桑原俊介
    • Organizer
      日本化学会, 第93春季年会
    • Place of Presentation
      草津
    • Year and Date
      2013-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] 2-メントキシ安息香酸による芳香族アルコールの光学分割・絶対配置決定2013

    • Author(s)
      田崎信由, 幅田揚一, 桑原俊介
    • Organizer
      日本化学会, 第93春季年会
    • Place of Presentation
      草津
    • Year and Date
      2013-03-23
    • Related Report
      2012 Final Research Report
  • [Presentation] DNAの構造制御を目指した新規分子モーターの合成研究2012

    • Author(s)
      野口敏明, 幅田揚一, 桑原俊介
    • Organizer
      日本化学会, 第2回化学フェスタ
    • Place of Presentation
      東京
    • Year and Date
      2012-10-16
    • Related Report
      2012 Final Research Report
  • [Presentation] 芳香族アルコールの光学分割・絶対配置決定を目指した2-メントキシ安息香酸の開発2012

    • Author(s)
      田崎信由・幅田揚一・桑原俊介
    • Organizer
      日本化学会, 第2回化学フェスタ
    • Place of Presentation
      東京
    • Year and Date
      2012-10-16
    • Related Report
      2012 Final Research Report
  • [Presentation] DNAの構造制御を目指した光駆動型分子モーターの合成研究2012

    • Author(s)
      野口敏明, 幅田揚一, 桑原俊介
    • Organizer
      日本化学会, 第92春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2012-03-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 2-メントキシ安息香酸:芳香族アルコールの光学分割・絶対配置決定試薬2012

    • Author(s)
      田崎信由, 幅田揚一, 桑原俊介
    • Organizer
      日本化学会, 第92春季年会
    • Place of Presentation
      横浜
    • Year and Date
      2012-03-26
    • Related Report
      2012 Final Research Report
  • [Presentation] DNAの構造制御を目指した光駆動型分子モーターの合成研究2012

    • Author(s)
      野口敏明・幅田揚一・桑原俊介
    • Organizer
      日本化学会第92春季年会
    • Place of Presentation
      横浜,慶応義塾大学
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規2-メントキシ安息香酸:芳香族アルコールの光学分割-絶対配置決定用試薬2011

    • Author(s)
      田崎信由, 幅田揚一, 桑原俊介
    • Organizer
      第22回基礎有機化学討論会
    • Place of Presentation
      つくば
    • Year and Date
      2011-09-22
    • Related Report
      2012 Final Research Report
  • [Presentation] DNAの構造制御を目指した複素環型分子モーターの合成研究

    • Author(s)
      野口敏明
    • Organizer
      日本化学会, 第93春季年会
    • Place of Presentation
      立命館大学, 草津市
    • Related Report
      2012 Annual Research Report
  • [Presentation] DNAの構造制御を目指した新規分子モーターの合成研究

    • Author(s)
      野口敏明
    • Organizer
      日本化学会, 第2回化学フェスタ
    • Place of Presentation
      東京工業大学, 東京都
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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