Synthetic Study of A Heterocyclic Molecular Motor Toward DNA Conformational Change
Project/Area Number |
22750159
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Chemistry related to living body
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Research Institution | Toho University |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 分子マシン / 分子モーター / DNA / 光スイッチ / 光異性化 |
Research Abstract |
We have designed a new heterocyclic molecular motor 2, which would intercalate in the DNA and induce conformational change of the DNA structure. Heterocyclic molecular motors (±)-trans-8and (±)-cis-8were prepared by the McMurry coupling and Buchwald-Hartwig reaction of heterocyclic ketone (±)-7d. The relative stereochemistry of (±)-trans-8and (±)-cis-8was determined as (2R*,2'R*)-(P*,P*) by X- ray crystallography. CD spectral titration experiments exhibit that significant conformational changes of B-DNA are not induced by (±)-trans-10and (±)-cis-10.
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Report
(4 results)
Research Products
(11 results)