Development of a novel method to enhance localized heating by cavitation bubbles for ultrasound cancer treatment

• Project/Area Number: 22760119
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Fluid engineering
• Research Institution: Tohoku University
• Principal Investigator: YOSHIZAWA Shin 東北大学, 大学院・工学研究科, 助教 (30455802)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: バイオ流体力学 / 超音波治療 / キャビテーション / 強力集束超音波

Research Abstract

High-intensity focused ultrasound (HIFU)therapy is attracting attention as a noninvasive therapeutic modality for cancer. However, it has a problem of long treatment time. It is known that acoustic cavitation generated in the focal region of HIFU enhances tissue heating. In this study, the behavior of cavitation bubbles were observed and scattered pressure waves from the bubbles were detected and investigated for the cavitation monitoring. The optical pressure measurement method was also investigated.

Research Products

• [Journal Article] Cavitation Inception by Dual-Frequency Excitation in High-Intensity Focused Ultrasound Treatment (2011)
  • Author(s): R. Takagi, S. Yoshizawa, S. Umemura
  • Journal Title: Jpn. J. Appl. Phys Volume: 50 Pages: 7-14
  • NAID: 210000070963
  • Peer Reviewed
• [Journal Article] 超音波パルスの照射条件が微小気泡の体積振動に与える影響(メカニカルインデックスと振動特性について) (2011)
  • Author(s): 宮本武司, 吉澤晋, 松本洋一郎
  • Journal Title: 日本機械学会論文集(B編) Volume: Vol.77, No.774 Pages: 264-273
  • NAID: 130000873938
  • Peer Reviewed
• [Journal Article] Cavitation Inception by Dual-Frequency Excitation in High-Intensity Focused Ultrasound Treatment (2011)
  • Author(s): R. Takagi, S. Yoshizawa and S.Umemura
  • Journal Title: Japanese Journal of Applied Physics Volume: vol. 50, no. 7 Issue: 7S Pages: 07HF14-07HF14
  • DOI: 10.1143/jjap.50.07hf14
  • NAID: 210000070963
  • Peer Reviewed
• [Presentation] Thermal simulation of cavitation enhanced ultrasonic heating verified with tissue mimicking gel (2011)
  • Author(s): 森山達也, 浅井歩, 吉澤晋, 梅村晋一郎
  • Organizer: 第32回超音波エレクトロニクスの基礎と応用に関するシンポジウム
  • Place of Presentation: 京都大学(京都)
  • Year and Date: 2011-11-10
• [Presentation] Efficient generation of cavitation cloud by dual-frequency ultrasound exposure (2011)
  • Author(s): 安田惇, 高木亮, 吉澤晋, 梅村晋一郎
  • Organizer: 第32回超音波エレクトロニクスの基礎と応用に関するシンポジウム
  • Place of Presentation: 京都大学(京郡)
  • Year and Date: 2011-11-10
• [Presentation] Cavitation Inception and Growth by Dual-Frequency Excitation in High-Intensity Focused Ultrasound Treatment (2011)
  • Author(s): S. Yoshizawa, J. Yasuda, S. Umemura
  • Organizer: 2011 IEEE International Ultrasonics Symposium
  • Place of Presentation: Orlando, USA
  • Year and Date: 2011-10-19
• [Presentation] Cavitation Inception and Growth by Dual-Frequency Excitation in High-Intensity Focused Ultrasound Treatment (2011)
  • Author(s): S.Yoshizawa, J.Yasuda, S.Umemura
  • Organizer: 2011 IEEE International Ultrasonics Symposium
  • Place of Presentation: オーランド(米国)
  • Year and Date: 2011-10-19
• [Presentation] 強力集束超音波治療におけるキャビテーション気泡の加熱増強作用 (2011)
  • Author(s): 吉澤晋, 稲葉脩太, 岩崎永子, 森山達也, 梅村晋一郎
  • Organizer: 第50回日本生体医工学会大会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-01
• [Presentation] 強力集束超音波治療におけるキャビテーション気泡の加熱増強作用 (2011)
  • Author(s): 吉澤晋, 稲葉脩太, 岩崎永子, 森山達也, 梅村晋一郎
  • Organizer: 第50回日本生体医工学会大会
  • Place of Presentation: 東京電機大学(東京)
  • Year and Date: 2011-05-01
• [Presentation] Cavitation Inception and Growth by Dual-Frequency Excitation Method (2011)
  • Author(s): S. Yoshizawa, R. Takagi, J. Yasuda, S. Umemura
  • Organizer: 11th International Symposium on Therapeutic Ultrasound
  • Place of Presentation: New York, USA
  • Year and Date: 2011-04-11
• [Presentation] Cavitation Inception and Growth by Dual-Frequency Excitation Method (2011)
  • Author(s): S.Yoshizawa, R.Takagi, J.Yasuda, S.Umemura
  • Organizer: 11th International Symposium on Therapeutic Ultrasound
  • Place of Presentation: ニューヨーク(米国)
  • Year and Date: 2011-04-11
• [Presentation] 集束超音波音場の光学的計測に関する研究 (2010)
  • Author(s): 大村, 島崎, 吉澤, 梅村
  • Organizer: The 31st Symposium on Ultrasonic Electronics (USE 2010)
  • Place of Presentation: 東京
  • Year and Date: 2010-12-06
• [Presentation] 3D reconstruction of ultrasonic fields from optical measurement (2010)
  • Author(s): R. Omura, Y. Shimazaki, S. Yoshizawa, S. Umemura
  • Organizer: 2010 IEEE International Ultrasonics Symposium
  • Place of Presentation: San Diego, USA
  • Year and Date: 2010-10-12
• [Presentation] 3D reconstruction of ultrasonic fields from optical measurement (2010)
  • Author(s): R.Omura, Y.Shimazaki, S.Yoshizawa, S.Umemura
  • Organizer: 2010 IEEE International Ultrasonics Symposium
  • Place of Presentation: サンディエゴ,米国
  • Year and Date: 2010-10-12
• [Remarks]
  • URL: http://www.ecei.tohoku.ac.jp/ume/
• [Remarks]
  • URL: http://www.ecei.tohoku.ac.jp/ume/results/research_index.html