| Project/Area Number |
22760170
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dynamics/Control
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| Research Institution | Yokohama National University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 機械力学・制御 / モデル化 / 細胞組織 / シグナル伝達 / 振動 / 振動数 / 骨芽細胞 / 骨 / 細胞・組織 |
|---|
| Research Abstract |
This report describes that a dynamic model of mechanical sensing system of an osteoblast is constructed by considering a cell as an intelligent structural system with sensors, controllers, and actuators, and that the effective frequency and amplitude of mechanical vibration on bone formation is identified. As a result, we have developed an experimental method to obtain the relationship between mechanical deformation and biochemical response of a cell and have shown that the mechanical sensing system of a cell can be modeled. Furthermore, we have shown that the cell proliferation is promoted with decreasing the vibration frequency and that 50 Hz is the effective frequency of bone formation.
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