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NADH-fluorometric biochemical gas sensor using UV-LED

Research Project

Project/Area Number 22760246
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Electron device/Electronic equipment
Research InstitutionTokyo Medical and Dental University

Principal Investigator

KUDO Hiroyuki  東京医科歯科大学, 生体材料工学研究所, 講師 (70329118)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywordsバイオデバイス / ガスセンサ / バイオセンサ / 環境計測
Research Abstract

High sensitive and high selective fiber-optic biochemical gas sensor was constructed and tested. The biochemical gas sensor measures fluorescence of NADH, which is the product of formaldehyde dehydrogenase reaction. Using ultraviolet LED as an excitation source, and flow-cell with enzyme immobilized membrane, indoor formaldehyde was successfully measured at sub-ppb sensitivity.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (31 results)

All 2012 2011 2010

All Journal Article (10 results) (of which Peer Reviewed: 5 results) Presentation (19 results) Book (2 results)

  • [Journal Article] Fiber-optic biochemical gas sensor(bio-sniffer) for sub-ppb monitoring offormaldehyde vapor, Sens2012

    • Author(s)
      Kudo H, Wang X, Suzuki Y, Ye M, Yamashita T, Gessei T, Miyajima K, Arakawa T, Mitsubayashi K
    • Journal Title

      Actuators B Chem

      Volume: 161 Pages: 486-492

    • Related Report
      2011 Final Research Report
  • [Journal Article] Fiber-optic biochemical gas sensor (bio-sniffer) for sub-ppb monitoring of formaldehyde vapor2012

    • Author(s)
      Kudo H, Wang X, Suzuki Y, Ye M, Yamashita T, Gessei T, Miyajima K, Arakawa T, Mitsubayashi K
    • Journal Title

      Sens.Actuators B Chem

      Volume: 161 Issue: 1 Pages: 486-492

    • DOI

      10.1016/j.snb.2011.10.065

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biosensor for L-phenylalanine based on theoptical detection of NADH using a UV lightemitting diode2011

    • Author(s)
      Arakawa T, Koshida T, Gessei T, Miyajima K, Takahashi D, Kudo H, Yano K, Mitsubayashi K
    • Journal Title

      Microchimica acta

      Volume: 173 Pages: 199-205

    • Related Report
      2011 Final Research Report
  • [Journal Article] Biosensor for L-phenylalanine based on the optical detection of NADH using a UV light emitting diode2011

    • Author(s)
      Arakawa T, Koshida T, Gessei T, Miyajima K, Takahashi D, Kudo H, Yano K, Mitsubayashi K
    • Journal Title

      Microchimica acta

      Volume: 173 Issue: 1-2 Pages: 199-205

    • DOI

      10.1007/s00604-010-0536-5

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biochemical gassensor(bio-sniffer) for ultrahigh-sensitivegaseous formaldehyde monitoring2010

    • Author(s)
      Kudo H, Suzuki Y, Gessei T, Takahashi D, Arakawa T, Mitsubayashi K
    • Journal Title

      Biosensorsand Bioelectronics

      Volume: 26 Pages: 854-858

    • Related Report
      2011 Final Research Report
  • [Journal Article] Fiberoptic bio-sniffer(biochemical gas sensor) for highselective monitoring of ethanol vapor using 335nm UV-LED, Sens2010

    • Author(s)
      Kudo H, Sawai M, Suzuki Y, Wang X, Gessei T, Takahashi D, Arakawa T, Mitsubayashi K
    • Journal Title

      Actuator B-Chem

      Volume: 147 Pages: 676-680

    • Related Report
      2011 Final Research Report
  • [Journal Article] Fluorescence biosensing system with a UV-LEDexcitation for l-leucine detection, Sens2010

    • Author(s)
      Koshida T, Arakawa T, Gessei T, Takahashi D, Kudo H, Saito H, Yano K, Mitsubayashi K
    • Journal Title

      Actuator B-Chem

      Volume: 146 Pages: 177-182

    • Related Report
      2011 Final Research Report
  • [Journal Article] Biochemical gas sensor (bio-sniffer) for ultrahigh-sensitive gaseous formaldehyde monitoring2010

    • Author(s)
      Kudo H, Suzuki Y, Gessei T, Takahashi D, Arakawa T, Mitsubayashi K
    • Journal Title

      Biosensors and Bioelectronics

      Volume: 26 Pages: 854-858

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fiber optic bio-sniffer (biochemical gas sensor) for high selective monitoring of ethanol vapor using 335 nm UV-LED2010

    • Author(s)
      Kudo H, Sawai M, Suzuki Y, Wang X, Gessei T, Takahashi D, Arakawa T, Mitsubayashi K
    • Journal Title

      Sens.Actuator B-Chem

      Volume: 147 Pages: 676-680

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescence biosensing system with a UV-LED excitation for l-leucine detection2010

    • Author(s)
      Koshida T, Arakawa T, Gessei T, Takahashi D, Kudo H, Saito H, Yano K, Mitsubayashi K
    • Journal Title

      Sens.Actuator B-Chem

      Volume: 146 Pages: 177-182

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 環境と健康科学を指向したセンシングバイオロジーの現状と将来展望2011

    • Author(s)
      工藤寛之、荒川貴博三、林浩二
    • Organizer
      産総研計測技術研究グループセミナー
    • Place of Presentation
      つくば
    • Year and Date
      2011-04-27
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 医療と健康科学のためのバイオセンシングデバイス2011

    • Author(s)
      工藤寛之
    • Organizer
      電気学会・次世代センサ協議会合同センサ研究会
    • Place of Presentation
      石川
    • Related Report
      2011 Final Research Report
  • [Presentation] 医療と環境計測に向けたバイオセンシングシステムの現状と将来展望2011

    • Author(s)
      工藤寛之
    • Organizer
      次世代センサ協議会第61回研究会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Fiber opticbiosensor with UV LED for assessment offormaldehyde vapor in indoor environment2011

    • Author(s)
      Ye M, Yamashita T, Itabashi G, Gessei T, Wang X, Arakawa T, Kudo H, Mitsubayashi K
    • Organizer
      9th Asian Conference on Chemical Sensors
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2011 Final Research Report
  • [Presentation] High sensitive formaldehyde bio-sniffer(biochemical gas sensor) based on NADHfluorometry with UV-LED excitation2011

    • Author(s)
      Yamashita T, Itabashi G, Suzuki Y, Miyajima K, Arakawa T, Kudo H, Yano K, Mitsubayashi K
    • Organizer
      The 5thInternational Conference on Sensors
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2011 Final Research Report
  • [Presentation] Fibre-opticbiochemical gas sensor for high-sensitive and high-selective monitoring of environmentalformaldehyde2011

    • Author(s)
      Kudo H, Yamashita T, Ie M, Miyajima K, Wang X, Arakawa T, Mitsubayashi K
    • Organizer
      2nd International Conference on Bio-Sensing Technology 2011
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2011 Final Research Report
  • [Presentation] UV-LED励起光源を利用したホルムアルデヒドガス用バイオスニファ2011

    • Author(s)
      山下俊文,板橋玄,月精智子,宮島久美子,高橋大志,荒川貴博,工藤寛之,三林浩二
    • Organizer
      第1回次世代センサ研究発表会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 環境中ホルムアルデヒド評価のための生化学式ガスセンサ2011

    • Author(s)
      山下俊文,板橋玄,月精智子,宮島久美子,高橋大志,荒川貴博,工藤寛之,三林浩二
    • Organizer
      第58回応用物理学関係連合講演会
    • Place of Presentation
      厚木
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 医療と健康科学のためのバイオセンシングデバイス2011

    • Author(s)
      工藤寛之
    • Organizer
      電気学会・次世代センサ協議会合同センサ研究会
    • Place of Presentation
      金沢
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fiber optic biosensor with UV LED for assessment of formaldehyde vapor in indoor environment2011

    • Author(s)
      Ye M, Yamashita T, Itabashi G, Gessei T, Wang X, Arakawa T, Kudo H, Mitsubayashi K
    • Organizer
      9th Asian Conference on Chemical Sensors
    • Place of Presentation
      Taipei, Taiwan
    • Related Report
      2011 Annual Research Report
  • [Presentation] High sensitive formaldehyde bio-sniffer (biochemical gas sensor) based on NADH fluorometry with UV-LED excitation2011

    • Author(s)
      Yamashita T, Itabashi G, Suzuki Y, Miyajima K, Arakawa T, Kudo H, Yano K, Mitsubayashi K
    • Organizer
      The 5th International Conference on Sensors
    • Place of Presentation
      Jeju, Korea
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fibre-optic biochemical gas sensor for high-sensitive and high-selective monitoring of environmental formaldehyde2011

    • Author(s)
      Kudo H, Yamashita T, Ie M, Miyajima K, Wang X, Arakawa T, Mitsubayashi K
    • Organizer
      2nd International Conference on Bio-Sensing Technology 2011
    • Place of Presentation
      Amsterdam, Netherlands
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fiber-opticbiosensor for sorbitol-induced diabeticcomplications using an UV-LED excitation system2010

    • Author(s)
      Gessei T, Nagashima T, Takahashi D, Arakawa T, Kudo H, Shiba K, Mitsubyashi K
    • Organizer
      the 13th international meeting of chemical sensors(IMCS-13)
    • Place of Presentation
      Perth, Western Australia
    • Related Report
      2011 Final Research Report
  • [Presentation] Afluorometric-sniffer(biochemical gas sensor) usingUV-LED(340 nm) on NADH-excitation formonitoring ethanol vapor2010

    • Author(s)
      Sawai M, Suzuki Y, Itabashi G, Takahashi D, Arakawa T, Kudo H, Mitsubayashi K
    • Organizer
      the 13th international meeting of chemical sensors(IMCS-13)
    • Place of Presentation
      Perth, Western Australia
    • Related Report
      2011 Final Research Report
  • [Presentation] Fluorometric bio-sniffer(Optnose) based on NADH detection with UV-LED forcontinuous monitoring of residential formaldehydewith sub-ppb sensitivity2010

    • Author(s)
      Suzuki Y, Gessei T, Takahashi D, Arakawa T, KudoH, Mitsubayashi K
    • Organizer
      20th Anniversary WorldCongress on Biosensors
    • Place of Presentation
      BIOSENSORS2010, Glasgow, UK
    • Related Report
      2011 Final Research Report
  • [Presentation] 住環境中ホルムアルデヒドの高感度モニタリングを目的とした生化学式ガスセンサ2010

    • Author(s)
      山下俊文,板橋玄,月精智子,宮島久美子,高橋大志,荒川貴博,工藤寛之,三林浩二
    • Organizer
      第22回SASインテリジェントシンポジウム
    • Place of Presentation
      平塚
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] High-sensitive biochemical gas sensor (bio-sniffer) for evaluating detoxification of environmental formaldehyde2010

    • Author(s)
      Gessei T, Kudo H, Suzuki Y, Takahashi D, Arakawa T, Mitsubayashi K
    • Organizer
      the 13th international meeting of chemical sensors (IMCS-I3)
    • Place of Presentation
      Perth, Australia
    • Related Report
      2010 Annual Research Report
  • [Presentation] A fluorometric-sniffer (biochemical gas sensor) using UV-LED (340 nm) on NADH-excitation for monitoring ethanol vapor2010

    • Author(s)
      Sawai M, Suzuki Y, Itabashi G, Takahashi D, Arakawa T, Kudo H, Mitsubayashi K
    • Organizer
      the 13th international meeting of chemical sensors (IMCS-13)
    • Place of Presentation
      Perth, Australia
    • Related Report
      2010 Annual Research Report
  • [Presentation] Fluorometric bio-sniffer (Opt nose) based on NADH detection with UV-LED for continuous monitoring of residential formaldehyde with sub-ppbsensitivity2010

    • Author(s)
      Suzuki Y, Gessei T, Takahashi D, Arakawa T, Kudo H, Mitsubayashi K
    • Organizer
      20th Anniversary World Congress on Biosensors, BIOSE NSORS2010
    • Place of Presentation
      Glasgow, UK
    • Related Report
      2010 Annual Research Report
  • [Book] 2012医療用エレクトロニクス技術大全2012

    • Author(s)
      工藤寛之,三林浩二
    • Publisher
      電子ジャーナル
    • Related Report
      2011 Final Research Report
  • [Book] 2012医療用エレクトロニクス技術大全「第1編・第3章ヘルスケア向けデバイスの現状と動向」2012

    • Author(s)
      工藤寛之, 三林浩二
    • Total Pages
      168
    • Publisher
      電子ジャーナル
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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