Study on imaging system for analysis of endothelial vascular function by using RGB images

• Project/Area Number: 22760296
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Measurement engineering
• Research Institution: Tokyo University of Agriculture and Technology
• Principal Investigator: NISHIDATE Izumi 東京農工大学, 大学院・工学研究院, 准教授 (70375319)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 皮膚血流 / 血管拡張性 / 動脈血流入量 / 静脈容量 / 皮膚 / RGB画像 / RGBカメラ / 皮膚色素 / ヘモグロビン / 血液 / 血管内皮機能 / I型糖尿病 / ストレンゲージプレチスモグラフ / 可視化 / 血管拡張性指標

Research Abstract

To visualize the human skin hemodynamics, we investigated a method that is specifically developed for estimating the concentrations of oxygenated blood, deoxygenated blood, and total blood in skin tissue from RGB digital color images. The total blood concentration can also be reconstructed. In vivo imaging of rat dorsal skin flap during occlusion demonstrated the possibility of the method to evaluate endothelial function for blood vessels in skin tissue. In vivo imaging of the total blood concentration was performed for human subjects during the upper limb occlusion at 50 and 250 mmHg-pressures. The arterial inflow, the venous capacitance, maximum venous outflow, and time constant of recovery for reactive hyperemia in skin tissue were calculated from the increase rate and the change of the total blood concentration. We confirmed that the arterial inflow, the venous capacitance, maximum venous outflow, and time constant of recovery for reactive hyperemia can be successfully obtained by the proposed method.

Research Products

• [Journal Article] Noninvasive imaging of human skinhemodynamics using a digitalred-green-blue camera (2011)
  • Author(s): Izumi Nishidate, Noriyuki Tanaka, TatsuyaKawase, Takaaki Maeda, Tomonori Yuasa, Yoshihisa Aizu, Tetsuya Yuasa, Kyuichi Niizeki
  • Journal Title: Journal of Biomedical Optics Volume: Vol.16 Issue: 8 Pages: 1-14
  • DOI: 10.1117/1.3613929
  • Peer Reviewed
• [Journal Article] Non-invasive spectral imaging of skinchromophores based on multiple regressionanalysis aided by Monte Carlo simulation (2011)
  • Author(s): Izumi Nishidate, Aditya Wiswadarma, Yota Hase, Noriyuki Tanaka, Takaaki Maeda, Kyuichi Niizeki, and Yoshihisa Aizu
  • Journal Title: Opt. Lett Volume: Vol.36, No.16 Issue: 16 Pages: 3239-3241
  • DOI: 10.1364/ol.36.003239
  • Peer Reviewed
• [Presentation] 皮膚のカラー画像を用いた容積脈波の非接触計測 (2011)
  • Author(s): 川瀬達也, 田中規之, 及川広恵, 西舘泉, 新関久一, 相津佳永
  • Organizer: Optics & Photonics Japan 2011
  • Place of Presentation: 大阪大学吹田キャンパスコンベンションセンター(大阪府)
  • Year and Date: 2011-11-30
• [Presentation] Noninvasive and noncontact imaging of skin hemodynamics using a digital RGB camera (2011)
  • Author(s): I. Nishidate, T. Kawase, N. Tanaka, K. Niizeki, and Y. Aizu
  • Organizer: Japan-Korea Biomedical Optics Symposium, Optics & Photonics Japan 2011
  • Place of Presentation: Osaka, Japan
  • Year and Date: 2011-11-29
• [Presentation] RGB画像に基づくラット有茎皮弁の血行動態イメージング (2011)
  • Author(s): 田中規之,西舘泉,新関久一,相津佳永
  • Organizer: Optics & Photonics Japan 2011
  • Place of Presentation: 大阪大学吹田キャンパスコンベンションセンター(大阪府)
  • Year and Date: 2011-11-29
• [Presentation] Noninvasive and noncontact imaging of skin hemodynamics using a digital RGB camera (2011)
  • Author(s): I.Nishidate, T.Kawase, N.Tanaka, K.Niizeki, Y.Aizu
  • Organizer: Japan-Korea Biomedical Optics Symposium, Optics & Photonics Japan 2011
  • Place of Presentation: 大阪大学吹田キャンパスコンベンションセンター(大阪府)
  • Year and Date: 2011-11-29
• [Presentation] 皮膚のRGB画像を用いた容積脈波の非接触計測 (2011)
  • Author(s): 西舘泉, 川瀬達也, 及川広恵, 新関久一, 相津佳永
  • Organizer: 電気学会光・量子デバイス研究会
  • Place of Presentation: サピアタワー東北大学東京分室会議室(東京都)
  • Year and Date: 2011-09-26
• [Presentation] RGB画像から推定された分光反射率に基づく皮膚色素量の可視化 (2010)
  • Author(s): Aditya Wiswadarma
  • Organizer: 日本光学会年次学術講演会Optics& Photonics Japan 2010
  • Place of Presentation: 中央大学 駿河台記念館
  • Year and Date: 2010-11-10
• [Presentation] 皮膚のRGB画像による血管拡張性指標のイメージング (2010)
  • Author(s): 川瀬達也,田中規之,西舘泉,前田貴章,湯浅友典,湯浅哲也,新関久一,相津佳永
  • Organizer: Optics & Photonics Japan 2010
  • Place of Presentation: 中央大学駿河台記念館(東京都)
  • Year and Date: 2010-11-09
• [Presentation] 皮膚のRGB画像による血管拡張性指標のイメージング (2010)
  • Author(s): 川瀬達也
  • Organizer: 日本光学会年次学術講演会Optics& Photonics Japan 2010
  • Place of Presentation: 中央大学 駿河台記念館
  • Year and Date: 2010-11-09
• [Remarks]
  • URL: http://www.tuat.ac.jp/~bmp-mpg/index.html
• [Remarks]
  • URL: http://www.tuat.ac.jp/~bmp-mpg/index.html
• [Remarks]
  • URL: http://www.tuat.ac.jp/~bmp-mpg/index.html