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Development of immunosensors for healthcare

Research Project

Project/Area Number 22760306
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Measurement engineering
Research InstitutionOsaka Institute of Technology

Principal Investigator

KOIKE Kazuto  大阪工業大学, 工学部, 准教授 (40351457)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords酸化亜鉛 / 五酸化タンタル / 溶液ゲートトランジスター / pHセンサーアプタマー / 免疫グロブリン / 免疫センサー / pHセンサー / アプタマー / スパッタ成長 / pHセンサー / シランカップリング / アミノシラン分子 / バイオセンサー / トランジスター / ガラス基板 / 電解質溶液ゲート
Research Abstract

A prototype label-free immunosensor based on a ZnO solution-gate field-effect transistor with an aptamer-modified Ta2O5 gate surface was developed. The sensor showed a sensitive and rapid response to human immunogamma globulin.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (58 results)

All 2013 2012 2011 2010 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (36 results) (of which Invited: 1 results) Book (2 results) Remarks (4 results)

  • [Journal Article] 高性能酸化亜鉛系FETと酸化物デバイス応用の広がり2012

    • Author(s)
      佐々誠彦,矢野満明,前元利彦,小池一歩,尾形健一
    • Journal Title

      電子情報通信学会誌

      Volume: Vol.95-4 Pages: 289-293

    • NAID

      110009437460

    • URL

      http://ci.nii.ac.jp/naid/110009437460

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zinc oxide-based biosennsors2012

    • Author(s)
      Mitsuaki Yano Sigeru Omatu
    • Journal Title

      Phisica Statsu Solidai C

      Volume: 9 Issue: 7 Pages: 1570-1573

    • DOI

      10.1002/pssc.201100560

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Radiation hardness of single-crystalline zinc oxide films2012

    • Author(s)
      K. Koike, T. Aoki, R. Fujimoto, S. Sasa, M. Yano, S. Gonda, R. Ishigami, K. Kume
    • Journal Title

      Physica Status Solidi c

      Volume: Vol.9-7 Pages: 1577-1579

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 8MeV proton irradiation damage and its recovery by annealing on single-crystalline zinc oxide crystal2012

    • Author(s)
      K. Koike, R. Fujimoto, R. Wada, S. Sasa, M. Yano, S. Gonda, R. Ishigami, K. Kume
    • Journal Title

      MRS Symposium Proceedings

      Volume: Vol.1432, g10-02 Pages: 12-12

    • URL

      http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8537855

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高性能酸化亜鉛系FETと酸化物デバイス用の広がり2012

    • Author(s)
      佐々誠彦,矢野満明,前元利彦,小池一歩,尾形健一
    • Journal Title

      電子情報通信学会誌

      Volume: 95(4) Pages: 289-293

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of ZnO Transistors and Their Application to Bio-Sensors2011

    • Author(s)
      矢野満明, 小池一歩, 佐々誠彦, 前元利彦, 井上正崇
    • Journal Title

      Journal of the Society of Materials Science, Japan

      Volume: 60 Issue: 5 Pages: 447-456

    • DOI

      10.2472/jsms.60.447

    • NAID

      130000861066

    • ISSN
      0514-5163, 1880-7488
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Growth of Zinc Oxide Nanorods Via Aqueous Solution Process and Their Application for Biosensors2011

    • Author(s)
      尾形,土橋,小池,佐々,井上,矢野
    • Journal Title

      Journal of the Society of Materials Science, Japan

      Volume: 60 Issue: 11 Pages: 976-982

    • DOI

      10.2472/jsms.60.976

    • NAID

      130001396964

    • ISSN
      0514-5163, 1880-7488
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ele ctric Properties of Aqueous Grown ZnO Nanorods on Au/Ti/Si Substrates2011

    • Author(s)
      Kenichi Ogata, Hideaki Dobashi,Paul Russel, Kazuto Koike, Shigehiko Sas a,Masataka Inoue, Mitsuaki Yano
    • Journal Title

      Ph ysca Status Solidi (c)

      Volume: Vol. 8 Issue: 2 Pages: 522-524

    • DOI

      10.1002/pssc.201000521

    • Related Report
      2012 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Irradiation Effect of 8MeV Protons on Single-Crystalline Zinc Oxide Films2011

    • Author(s)
      小池,天野,青木,藤本,佐々,矢野,權田,石神,久米
    • Journal Title

      Journal of the Society of Materials Science, Japan

      Volume: 60 Issue: 11 Pages: 988-993

    • DOI

      10.2472/jsms.60.988

    • NAID

      130001396966

    • ISSN
      0514-5163, 1880-7488
    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electric properties of aqueous grown ZnO nanorods on Au/Ti/Si substrates2011

    • Author(s)
      Ken-ichi Ogata(第一著者)
    • Journal Title

      Phys.Stat.Solidi

      Volume: Vol.C8 Pages: 522-524

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of chemical stability of aqueous solution grown ZnO nanorods by aminosilane modification2010

    • Author(s)
      K. Ogata, H. Dobashi, K. Koike, S. Sasa, M. Inoue, M. Yano
    • Journal Title

      Physica Status Solidi c

      Volume: Vol.7-6 Issue: 6 Pages: 1562-1564

    • DOI

      10.1002/pssc.200983233

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] 高性能ZnO系FETの開発-デバイス応用と高周波特性-,電子情報通信学会2010

    • Author(s)
      佐々誠彦,小池一歩,前元利彦,矢野満明,井上正崇
    • Journal Title

      信学技報IEICEEechnicalReportED2009-184

      Volume: MW2009-167 Pages: 55-60

    • URL

      http://ci.nii.ac.jp/naid/110008000811

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Improvement of chemical stability of aqueous solution grown ZnO nanorods by a minosilane modification2010

    • Author(s)
      Ken-ichi Ogata(第一著者)
    • Journal Title

      Phys.Stat.Solidi

      Volume: C7 Pages: 1562-1564

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ZnO nanorods growth on sapphire substrates using aqueous solution with microwave heating and their photoluminescence properties2010

    • Author(s)
      Ken-ichi Ogata(第一著者)
    • Journal Title

      Phys.Stat.Solidi

      Volume: Vol.C7 Pages: 1592-1594

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Patterned growth of ZnO nanorods and enzyme immobilization toward the fabrication of glucose sensors2010

    • Author(s)
      Ken-ichi Ogata(第一著者)
    • Journal Title

      Physica E

      Volume: Vol.42 Pages: 2636-2639

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ga_<1-x>Al_xNとZn_<1-x>Mg_xOに関する第一原理計算を用いた分極状態の解析2010

    • Author(s)
      小池一歩(第一著者)
    • Journal Title

      材料

      Volume: Vol.59 Pages: 660-665

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新対向ターゲット式スパッタ法によるTa2O5/ZnO:Inヘテロ構造膜の作製と高感度pHセンサーへの応用2013

    • Author(s)
      向井和哉,大仲崇之,小池一歩, 前元利彦,佐々誠彦,矢野満明, 門倉貞夫,中光豊
    • Organizer
      第60回応用物理学会春季学術講演会
    • Place of Presentation
      神奈川工科大学,神奈川県
    • Related Report
      2012 Annual Research Report
  • [Presentation] Growth of a sputtered Ta2O5/ZnO film and its application to an ion-sensitive field-effect transistor2013

    • Author(s)
      K. Mukai, T. Onaka, K. Koike, T. Maemoto, S. Sasa, M. Yano
    • Organizer
      The 2013 International Meeting for Future of Electron Devices, Kansai
    • Place of Presentation
      Osaka (Japan)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 酸化亜鉛系イオン感応性電界効果トランジスターのpH検出特性2012

    • Author(s)
      田辺慎太朗,向井和哉,小池一歩,尾形健一,佐々誠彦,矢野満明
    • Organizer
      第59回応用物理学関係連合講演会
    • Place of Presentation
      早稲田大学
    • Year and Date
      2012-03-17
    • Related Report
      2012 Final Research Report 2011 Annual Research Report
  • [Presentation] 単結晶酸化亜鉛への8MeVプロトンビーム照射と熱処理効果2012

    • Author(s)
      藤本龍吾
    • Organizer
      第59回応用物理学関係連合講演会
    • Place of Presentation
      早稲田大学
    • Year and Date
      2012-03-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新対向ターゲット式スパッタ法による単結晶ZnO薄膜のエピタキシャル成長2012

    • Author(s)
      田辺慎太朗,向井和哉,小池一歩,前元利彦,佐々誠彦,矢野満明,門倉貞夫,中光豊
    • Organizer
      第73回応用物理学会学術講演会
    • Place of Presentation
      愛媛大学
    • Related Report
      2012 Final Research Report
  • [Presentation] 8MeV proton irradiation and post-annealing effect on single-crystalline zinc oxide crystals2012

    • Author(s)
      K. Koike, R. Fujimoto, R. Wada, S. Sasa, M. Yano, S. Gonda, R. Ishigami, K. Kume
    • Organizer
      MRS Spring Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2012 Final Research Report
  • [Presentation] 8MeV proton irradiation and post-annealing effect on single-crystalline zinc oxide crystals2012

    • Author(s)
      K. Koike, R. Fujimoto, R. Wada, S. Sasa, M. Yano, S. Gonda, R. Ishigami, K. Kume
    • Organizer
      2012 MRS Spring Meeting
    • Place of Presentation
      San Francisco (USA)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] ZnO nanorod growth on surface coated flexible polypropylene films using aqueous solution2012

    • Author(s)
      K. Ogata, K. Koike, S. Sasa, M. Inoue, M. Yano
    • Organizer
      International Association of Colloid and Interface Scientists Conference
    • Place of Presentation
      Sendai (Japan)
    • Related Report
      2012 Annual Research Report
  • [Presentation] ZnO nanorod growth from aqueous solution via microwave heating on paper substrates2012

    • Author(s)
      K. Ogata, K. Koike, S. Sasa, M. Inoue, M. Yano
    • Organizer
      International Workshop on Zinc Oxide and Related Materials
    • Place of Presentation
      Nice (France)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 新対向ターゲット式スパッタ法による単結晶ZnO薄膜のエピタキシャル成長2012

    • Author(s)
      田辺慎太朗,向井和哉,小池一歩, 前元利彦,佐々誠彦,矢野満明, 門倉貞夫,中光豊
    • Organizer
      第73回応用物理学会学術講演会
    • Place of Presentation
      愛媛・松山大学,愛媛県
    • Related Report
      2012 Annual Research Report
  • [Presentation] 多結晶ZnO/ZnMgOヘテロ構造を用いた溶液ゲート電界効果トランジスタのpHセンシング特性,日本材料学会半導体エレクトロニクス部門2011

    • Author(s)
      野上隆弘,田辺慎太朗,小池一歩,尾形健一,佐々誠彦,矢野満明
    • Organizer
      平成23年度第1回研究会
    • Place of Presentation
      神戸大学
    • Year and Date
      2011-11-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 多結晶ZnO/ZnMgOヘテロ構造を用いた溶液ゲート電界効果トランジスタのpHセンシング特性2011

    • Author(s)
      野上隆弘
    • Organizer
      日本材料学会半導体エレクトロニクス部門,平成23年度第1回研究会
    • Place of Presentation
      神戸大学
    • Year and Date
      2011-11-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Potentiometric detection of glucose using enzyme-immobilized ZnO nanorod arrays toward integration with field effect transistors2011

    • Author(s)
      K. Ogata, K. Koike, S. Sasa, M. Inoue, M. Yano
    • Organizer
      Int. Workshop on Quantum Nanostructures and Nanoelectronics QNN2011
    • Place of Presentation
      University of Tokyo
    • Year and Date
      2011-10-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Potentiometric detection of glucose using enzyme-immobilized ZnO nanorod arrays toward integration with field effect transistors2011

    • Author(s)
      Ken-ichi Ogata
    • Organizer
      International Workshop on Quantum Nanostructures and Nanoelectronics (QNN2011)
    • Place of Presentation
      東京大学
    • Year and Date
      2011-10-03
    • Related Report
      2011 Annual Research Report
  • [Presentation] 単結晶ZnO薄膜に対する8MeVプロトンビームの照射効果2011

    • Author(s)
      青木隆裕
    • Organizer
      第72回応用物理学会学術講演会
    • Place of Presentation
      山形大学
    • Year and Date
      2011-09-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Radiation hardness of ZnO2011

    • Author(s)
      Kazuto Koike
    • Organizer
      International Workshop on Advanced Materials and Devices
    • Place of Presentation
      大阪工業大学
    • Year and Date
      2011-08-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Growth of ZnO nanorods from aqueous solution by microwave heating and their application to high sensitive glucose detection2011

    • Author(s)
      Ken-ichi Ogata
    • Organizer
      International Workshop on Advanced Materials and Devices
    • Place of Presentation
      大阪工業大学
    • Year and Date
      2011-08-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Radiation hardness of ZnO/ZnMgO HFETs2011

    • Author(s)
      Tatsuya Yabe
    • Organizer
      International Workshop on Advanced Materials and Devices
    • Place of Presentation
      大阪工業大学
    • Year and Date
      2011-08-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Zinc oxide ion-sensitive FETs for biosensor applications2011

    • Author(s)
      Takahiro Nogami
    • Organizer
      International Workshop on Advanced Materials and Devices
    • Place of Presentation
      大阪工業大学
    • Year and Date
      2011-08-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Zinc oxide-based biosensors2011

    • Author(s)
      M. Yano, K. Koike, K. Ogata, T. Nogami, S. Tanabe, S. Sasa
    • Organizer
      16th Semiconducting and insulating Materials Conference (SIMC)
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2011-06-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Radiation hardness of single-crystalline ZnO2011

    • Author(s)
      Kazuto Koike
    • Organizer
      16th Semiconducting and Insulating Materials Conference (SIMC)
    • Place of Presentation
      The Royal Institute of Technology, Stockholm, Sweden
    • Year and Date
      2011-06-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Zinc oxide-based biosensors2011

    • Author(s)
      Mitsuaki Yano
    • Organizer
      16th Semiconducting and Insulating Materials Conference (SIMC)
    • Place of Presentation
      The Royal Institute of Technology, Stockholm, Sweden(招待講演)
    • Year and Date
      2011-06-21
    • Related Report
      2011 Annual Research Report
  • [Presentation] Irradiation effect of 8MeV protons on single-crystalline zinc oxide2011

    • Author(s)
      Takahiro Aoki
    • Organizer
      2011 International Meeting for Future of Electron Devices, Kansai
    • Place of Presentation
      関西大学
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Radiation-proof characteristic of ZnO/ZnMgO HFETs2011

    • Author(s)
      Tatsuya Yabe
    • Organizer
      2011 International Meeting for Future of Electron Devices, Kansai
    • Place of Presentation
      関西大学
    • Year and Date
      2011-05-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] 多結晶ZnO/ZnMgOヘテロ構造を用いた溶液ゲート電界効果トランジスターのバイオセンシング特性2011

    • Author(s)
      野上隆弘,小池一歩,尾形健一,佐々誠彦,井上正崇,矢野満明
    • Organizer
      第58回応用物理学関係連合講演会
    • Place of Presentation
      神奈川工科大学
    • Year and Date
      2011-03-25
    • Related Report
      2012 Final Research Report
  • [Presentation] 多結晶ZnO/ZnMgOヘテロ構造を用いた溶液ゲート電界効果トランジスターのバイオセンシング特性2011

    • Author(s)
      野上隆弘(代表名)
    • Organizer
      第58回応用物理学関係連合講演会
    • Place of Presentation
      神奈川工科大学(神奈川県)
    • Year and Date
      2011-03-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] バイオセンサ応用に向けた酸化亜鉛系イオン感応トランジスターの開発2010

    • Author(s)
      小池一歩,辻久美穂,野上隆弘,尾形健一,佐々誠彦,井上正崇,矢野満明
    • Organizer
      薄膜材料デバイス研究会第7回研究集会
    • Place of Presentation
      奈良100年会館
    • Year and Date
      2010-11-06
    • Related Report
      2012 Final Research Report
  • [Presentation] バイオセンサ応用に向けた酸化亜鉛系イオン感応トランジスタの開発2010

    • Author(s)
      小池一歩(代表名)
    • Organizer
      薄膜材料デバイス研究会 第7回研究集会
    • Place of Presentation
      奈良100年会館(奈良県)(招待講演)
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] M. Yano, Characteristics of microscale ion-sensitive ZnO/ZnMgO field-effect transistors formed on glass substrates2010

    • Author(s)
      K. Tsuji, T. Nogami, K. Koike, K. Ogata, S. Sasa, M. Inoue
    • Organizer
      29th Electronic Materials Sympo.
    • Place of Presentation
      Shizuoka
    • Year and Date
      2010-07-14
    • Related Report
      2012 Final Research Report
  • [Presentation] Characterization of microscale ion-sensitive ZnO/ZnMgO field-effect transistors for med on glass substrates2010

    • Author(s)
      辻久美穂(代表名)
    • Organizer
      29th Electronic Materials Symposium
    • Place of Presentation
      伊豆,ラフォーレ修善寺(静岡県)
    • Year and Date
      2010-07-14
    • Related Report
      2010 Annual Research Report
  • [Presentation] Micro-fabrication and characterization of an ion-sensitive ZnO-based transistor on a glass substrate2010

    • Author(s)
      K. Tsuji, K. Koike, K. Ogata, S. Sasa, M. Inoue, M. Yano
    • Organizer
      2010 Int. Meetingfor Future of Electron Devices
    • Place of Presentation
      kansai, kansai University
    • Year and Date
      2010-05-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Growth and device application of zinc oxide2010

    • Author(s)
      佐々誠彦(代表名)
    • Organizer
      2010 Int.Meeting for Future of Electron Devices
    • Place of Presentation
      関西大学(大阪府)
    • Year and Date
      2010-05-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Micro-fabrication and characterization of an ion-sensitive ZnO-based transistor on a glass substrate2010

    • Author(s)
      辻久美穂(代表名)
    • Organizer
      2010 Int.Meeting for Future of Electron Devices
    • Place of Presentation
      関西大学(大阪府)
    • Year and Date
      2010-05-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] ガラス基板上へのイオン感応性酸化亜鉛トランジスターの作製と評価2010

    • Author(s)
      辻久美穂,野上隆弘,小池一歩,尾形健一,佐々誠彦,井上正崇,矢野満明
    • Organizer
      日本材料学会半導体エレクトロニクス部門,平成22年度第1回研究会
    • Place of Presentation
      大阪大学
    • Year and Date
      2010-05-08
    • Related Report
      2012 Final Research Report
  • [Presentation] ガラス基板上へのイオン感応性酸化亜鉛トランジスターの作製と評価2010

    • Author(s)
      辻久美穂(代表名)
    • Organizer
      日本材料学会半導体エレクトロニクス部門研究会
    • Place of Presentation
      大阪大学(大阪府)
    • Year and Date
      2010-05-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] ZnOナノロッドへの酵素固定化とグルコースセンシング2010

    • Author(s)
      土橋秀章(代表名)
    • Organizer
      日本材料学会半導体エレクトロニクス部門研究会
    • Place of Presentation
      大阪大学(大阪府)
    • Year and Date
      2010-05-08
    • Related Report
      2010 Annual Research Report
  • [Book] 酸化亜鉛の最先端技術と将来2011

    • Author(s)
      小池一歩
    • Publisher
      シーエムシー出版
    • Related Report
      2012 Final Research Report
  • [Book] 酸化亜鉛の最先端技術と将来,監修:山本哲也,6章2節「バイオセンサー」執筆2011

    • Author(s)
      小池一歩(6章2節 第一著者)
    • Publisher
      シーエムシー
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.oit.ac.jp/elc/~koike/

    • Related Report
      2012 Final Research Report
  • [Remarks] 研究代表者の研究室HP

    • URL

      http://www.oit.ac.jp/elc/~koike/

    • Related Report
      2012 Annual Research Report
  • [Remarks] 研究代表者が所属する研究センターHP

    • URL

      http://www.oit.ac.jp/japanese/nanotech/

    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.oit.ac.jp/elc/~koike/

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2019-07-29  

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