Development of immunosensors for healthcare

• Project/Area Number: 22760306
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Measurement engineering
• Research Institution: Osaka Institute of Technology
• Principal Investigator: KOIKE Kazuto 大阪工業大学, 工学部, 准教授 (40351457)
• Project Period (FY): 2010 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 酸化亜鉛 / 五酸化タンタル / 溶液ゲートトランジスター / pHセンサーアプタマー / 免疫グロブリン / 免疫センサー / ｐＨセンサー / アプタマー / スパッタ成長 / pHセンサー / シランカップリング / アミノシラン分子 / バイオセンサー / トランジスター / ガラス基板 / 電解質溶液ゲート

Research Abstract

A prototype label-free immunosensor based on a ZnO solution-gate field-effect transistor with an aptamer-modified Ta2O5 gate surface was developed. The sensor showed a sensitive and rapid response to human immunogamma globulin.

Research Products

• [Journal Article] 高性能酸化亜鉛系FETと酸化物デバイス応用の広がり (2012)
  • Author(s): 佐々誠彦,矢野満明,前元利彦,小池一歩,尾形健一
  • Journal Title: 電子情報通信学会誌 Volume: Vol.95-4 Pages: 289-293
  • NAID: 110009437460
  • URL: http://ci.nii.ac.jp/naid/110009437460
  • Peer Reviewed
• [Journal Article] Zinc oxide-based biosennsors (2012)
  • Author(s): Mitsuaki Yano Sigeru Omatu
  • Journal Title: Phisica Statsu Solidai C Volume: 9 Issue: 7 Pages: 1570-1573
  • DOI: 10.1002/pssc.201100560
  • Peer Reviewed
• [Journal Article] Radiation hardness of single-crystalline zinc oxide films (2012)
  • Author(s): K. Koike, T. Aoki, R. Fujimoto, S. Sasa, M. Yano, S. Gonda, R. Ishigami, K. Kume
  • Journal Title: Physica Status Solidi c Volume: Vol.9-7 Pages: 1577-1579
  • Peer Reviewed
• [Journal Article] 8MeV proton irradiation damage and its recovery by annealing on single-crystalline zinc oxide crystal (2012)
  • Author(s): K. Koike, R. Fujimoto, R. Wada, S. Sasa, M. Yano, S. Gonda, R. Ishigami, K. Kume
  • Journal Title: MRS Symposium Proceedings Volume: Vol.1432, g10-02 Pages: 12-12
  • URL: http://journals.cambridge.org/action/displayAbstract?fromPage=online&aid=8537855
  • Peer Reviewed
• [Journal Article] 高性能酸化亜鉛系ＦＥＴと酸化物デバイス用の広がり (2012)
  • Author(s): 佐々誠彦，矢野満明，前元利彦，小池一歩，尾形健一
  • Journal Title: 電子情報通信学会誌 Volume: 95(4) Pages: 289-293
  • Peer Reviewed
• [Journal Article] Development of ZnO Transistors and Their Application to Bio-Sensors (2011)
  • Author(s): 矢野満明, 小池一歩, 佐々誠彦, 前元利彦, 井上正崇
  • Journal Title: Journal of the Society of Materials Science, Japan Volume: 60 Issue: 5 Pages: 447-456
  • DOI: 10.2472/jsms.60.447
  • NAID: 130000861066
  • ISSN: 0514-5163, 1880-7488
  • Peer Reviewed
• [Journal Article] Growth of Zinc Oxide Nanorods Via Aqueous Solution Process and Their Application for Biosensors (2011)
  • Author(s): 尾形,土橋,小池,佐々,井上,矢野
  • Journal Title: Journal of the Society of Materials Science, Japan Volume: 60 Issue: 11 Pages: 976-982
  • DOI: 10.2472/jsms.60.976
  • NAID: 130001396964
  • ISSN: 0514-5163, 1880-7488
  • Peer Reviewed
• [Journal Article] Ele ctric Properties of Aqueous Grown ZnO Nanorods on Au/Ti/Si Substrates (2011)
  • Author(s): Kenichi Ogata, Hideaki Dobashi,Paul Russel, Kazuto Koike, Shigehiko Sas a,Masataka Inoue, Mitsuaki Yano
  • Journal Title: Ph ysca Status Solidi (c) Volume: Vol. 8 Issue: 2 Pages: 522-524
  • DOI: 10.1002/pssc.201000521
  • Peer Reviewed
• [Journal Article] Irradiation Effect of 8MeV Protons on Single-Crystalline Zinc Oxide Films (2011)
  • Author(s): 小池,天野,青木,藤本,佐々,矢野,權田,石神,久米
  • Journal Title: Journal of the Society of Materials Science, Japan Volume: 60 Issue: 11 Pages: 988-993
  • DOI: 10.2472/jsms.60.988
  • NAID: 130001396966
  • ISSN: 0514-5163, 1880-7488
  • Peer Reviewed
• [Journal Article] Electric properties of aqueous grown ZnO nanorods on Au/Ti/Si substrates (2011)
  • Author(s): Ken-ichi Ogata(第一著者)
  • Journal Title: Phys.Stat.Solidi Volume: Vol.C8 Pages: 522-524
  • Peer Reviewed
• [Journal Article] Improvement of chemical stability of aqueous solution grown ZnO nanorods by aminosilane modification (2010)
  • Author(s): K. Ogata, H. Dobashi, K. Koike, S. Sasa, M. Inoue, M. Yano
  • Journal Title: Physica Status Solidi c Volume: Vol.7-6 Issue: 6 Pages: 1562-1564
  • DOI: 10.1002/pssc.200983233
  • Peer Reviewed
• [Journal Article] 高性能ZnO系FETの開発-デバイス応用と高周波特性-,電子情報通信学会 (2010)
  • Author(s): 佐々誠彦,小池一歩,前元利彦,矢野満明,井上正崇
  • Journal Title: 信学技報IEICEEechnicalReportED2009-184 Volume: MW2009-167 Pages: 55-60
  • URL: http://ci.nii.ac.jp/naid/110008000811
  • Peer Reviewed
• [Journal Article] Improvement of chemical stability of aqueous solution grown ZnO nanorods by a minosilane modification (2010)
  • Author(s): Ken-ichi Ogata(第一著者)
  • Journal Title: Phys.Stat.Solidi Volume: C7 Pages: 1562-1564
  • Peer Reviewed
• [Journal Article] ZnO nanorods growth on sapphire substrates using aqueous solution with microwave heating and their photoluminescence properties (2010)
  • Author(s): Ken-ichi Ogata(第一著者)
  • Journal Title: Phys.Stat.Solidi Volume: Vol.C7 Pages: 1592-1594
  • Peer Reviewed
• [Journal Article] Patterned growth of ZnO nanorods and enzyme immobilization toward the fabrication of glucose sensors (2010)
  • Author(s): Ken-ichi Ogata(第一著者)
  • Journal Title: Physica E Volume: Vol.42 Pages: 2636-2639
  • Peer Reviewed
• [Journal Article] Ga_<1-x>Al_xNとZn_<1-x>Mg_xOに関する第一原理計算を用いた分極状態の解析 (2010)
  • Author(s): 小池一歩(第一著者)
  • Journal Title: 材料 Volume: Vol.59 Pages: 660-665
  • Peer Reviewed
• [Presentation] 新対向ターゲット式スパッタ法によるTa2O5/ZnO:Inヘテロ構造膜の作製と高感度pHセンサーへの応用 (2013)
  • Author(s): 向井和哉，大仲崇之，小池一歩， 前元利彦，佐々誠彦，矢野満明， 門倉貞夫，中光豊
  • Organizer: 第60回応用物理学会春季学術講演会
  • Place of Presentation: 神奈川工科大学，神奈川県
• [Presentation] Growth of a sputtered Ta2O5/ZnO film and its application to an ion-sensitive field-effect transistor (2013)
  • Author(s): K. Mukai, T. Onaka, K. Koike, T. Maemoto, S. Sasa, M. Yano
  • Organizer: The 2013 International Meeting for Future of Electron Devices, Kansai
  • Place of Presentation: Osaka (Japan)
• [Presentation] 酸化亜鉛系イオン感応性電界効果トランジスターのpH検出特性 (2012)
  • Author(s): 田辺慎太朗,向井和哉,小池一歩,尾形健一,佐々誠彦,矢野満明
  • Organizer: 第59回応用物理学関係連合講演会
  • Place of Presentation: 早稲田大学
  • Year and Date: 2012-03-17
• [Presentation] 単結晶酸化亜鉛への8MeVプロトンビーム照射と熱処理効果 (2012)
  • Author(s): 藤本龍吾
  • Organizer: 第59回応用物理学関係連合講演会
  • Place of Presentation: 早稲田大学
  • Year and Date: 2012-03-15
• [Presentation] 新対向ターゲット式スパッタ法による単結晶ZnO薄膜のエピタキシャル成長 (2012)
  • Author(s): 田辺慎太朗,向井和哉,小池一歩,前元利彦,佐々誠彦,矢野満明,門倉貞夫,中光豊
  • Organizer: 第73回応用物理学会学術講演会
  • Place of Presentation: 愛媛大学
• [Presentation] 8MeV proton irradiation and post-annealing effect on single-crystalline zinc oxide crystals (2012)
  • Author(s): K. Koike, R. Fujimoto, R. Wada, S. Sasa, M. Yano, S. Gonda, R. Ishigami, K. Kume
  • Organizer: MRS Spring Meeting
  • Place of Presentation: San Francisco, USA
• [Presentation] 8MeV proton irradiation and post-annealing effect on single-crystalline zinc oxide crystals (2012)
  • Author(s): K. Koike, R. Fujimoto, R. Wada, S. Sasa, M. Yano, S. Gonda, R. Ishigami, K. Kume
  • Organizer: 2012 MRS Spring Meeting
  • Place of Presentation: San Francisco (USA)
  • Invited
• [Presentation] ZnO nanorod growth on surface coated flexible polypropylene films using aqueous solution (2012)
  • Author(s): K. Ogata, K. Koike, S. Sasa, M. Inoue, M. Yano
  • Organizer: International Association of Colloid and Interface Scientists Conference
  • Place of Presentation: Sendai (Japan)
• [Presentation] ZnO nanorod growth from aqueous solution via microwave heating on paper substrates (2012)
  • Author(s): K. Ogata, K. Koike, S. Sasa, M. Inoue, M. Yano
  • Organizer: International Workshop on Zinc Oxide and Related Materials
  • Place of Presentation: Nice (France)
• [Presentation] 新対向ターゲット式スパッタ法による単結晶ZnO薄膜のエピタキシャル成長 (2012)
  • Author(s): 田辺慎太朗，向井和哉，小池一歩， 前元利彦，佐々誠彦，矢野満明， 門倉貞夫，中光豊
  • Organizer: 第73回応用物理学会学術講演会
  • Place of Presentation: 愛媛・松山大学，愛媛県
• [Presentation] 多結晶ZnO/ZnMgOヘテロ構造を用いた溶液ゲート電界効果トランジスタのpHセンシング特性,日本材料学会半導体エレクトロニクス部門 (2011)
  • Author(s): 野上隆弘,田辺慎太朗,小池一歩,尾形健一,佐々誠彦,矢野満明
  • Organizer: 平成23年度第1回研究会
  • Place of Presentation: 神戸大学
  • Year and Date: 2011-11-21
• [Presentation] 多結晶ZnO/ZnMgOヘテロ構造を用いた溶液ゲート電界効果トランジスタのpHセンシング特性 (2011)
  • Author(s): 野上隆弘
  • Organizer: 日本材料学会半導体エレクトロニクス部門,平成23年度第1回研究会
  • Place of Presentation: 神戸大学
  • Year and Date: 2011-11-21
• [Presentation] Potentiometric detection of glucose using enzyme-immobilized ZnO nanorod arrays toward integration with field effect transistors (2011)
  • Author(s): K. Ogata, K. Koike, S. Sasa, M. Inoue, M. Yano
  • Organizer: Int. Workshop on Quantum Nanostructures and Nanoelectronics QNN2011
  • Place of Presentation: University of Tokyo
  • Year and Date: 2011-10-03
• [Presentation] Potentiometric detection of glucose using enzyme-immobilized ZnO nanorod arrays toward integration with field effect transistors (2011)
  • Author(s): Ken-ichi Ogata
  • Organizer: International Workshop on Quantum Nanostructures and Nanoelectronics (QNN2011)
  • Place of Presentation: 東京大学
  • Year and Date: 2011-10-03
• [Presentation] 単結晶ZnO薄膜に対する8MeVプロトンビームの照射効果 (2011)
  • Author(s): 青木隆裕
  • Organizer: 第72回応用物理学会学術講演会
  • Place of Presentation: 山形大学
  • Year and Date: 2011-09-01
• [Presentation] Radiation hardness of ZnO (2011)
  • Author(s): Kazuto Koike
  • Organizer: International Workshop on Advanced Materials and Devices
  • Place of Presentation: 大阪工業大学
  • Year and Date: 2011-08-23
• [Presentation] Growth of ZnO nanorods from aqueous solution by microwave heating and their application to high sensitive glucose detection (2011)
  • Author(s): Ken-ichi Ogata
  • Organizer: International Workshop on Advanced Materials and Devices
  • Place of Presentation: 大阪工業大学
  • Year and Date: 2011-08-23
• [Presentation] Radiation hardness of ZnO/ZnMgO HFETs (2011)
  • Author(s): Tatsuya Yabe
  • Organizer: International Workshop on Advanced Materials and Devices
  • Place of Presentation: 大阪工業大学
  • Year and Date: 2011-08-23
• [Presentation] Zinc oxide ion-sensitive FETs for biosensor applications (2011)
  • Author(s): Takahiro Nogami
  • Organizer: International Workshop on Advanced Materials and Devices
  • Place of Presentation: 大阪工業大学
  • Year and Date: 2011-08-23
• [Presentation] Zinc oxide-based biosensors (2011)
  • Author(s): M. Yano, K. Koike, K. Ogata, T. Nogami, S. Tanabe, S. Sasa
  • Organizer: 16th Semiconducting and insulating Materials Conference (SIMC)
  • Place of Presentation: Stockholm, Sweden
  • Year and Date: 2011-06-21
• [Presentation] Radiation hardness of single-crystalline ZnO (2011)
  • Author(s): Kazuto Koike
  • Organizer: 16th Semiconducting and Insulating Materials Conference (SIMC)
  • Place of Presentation: The Royal Institute of Technology, Stockholm, Sweden
  • Year and Date: 2011-06-21
• [Presentation] Zinc oxide-based biosensors (2011)
  • Author(s): Mitsuaki Yano
  • Organizer: 16th Semiconducting and Insulating Materials Conference (SIMC)
  • Place of Presentation: The Royal Institute of Technology, Stockholm, Sweden(招待講演)
  • Year and Date: 2011-06-21
• [Presentation] Irradiation effect of 8MeV protons on single-crystalline zinc oxide (2011)
  • Author(s): Takahiro Aoki
  • Organizer: 2011 International Meeting for Future of Electron Devices, Kansai
  • Place of Presentation: 関西大学
  • Year and Date: 2011-05-19
• [Presentation] Radiation-proof characteristic of ZnO/ZnMgO HFETs (2011)
  • Author(s): Tatsuya Yabe
  • Organizer: 2011 International Meeting for Future of Electron Devices, Kansai
  • Place of Presentation: 関西大学
  • Year and Date: 2011-05-19
• [Presentation] 多結晶ZnO/ZnMgOヘテロ構造を用いた溶液ゲート電界効果トランジスターのバイオセンシング特性 (2011)
  • Author(s): 野上隆弘,小池一歩,尾形健一,佐々誠彦,井上正崇,矢野満明
  • Organizer: 第58回応用物理学関係連合講演会
  • Place of Presentation: 神奈川工科大学
  • Year and Date: 2011-03-25
• [Presentation] 多結晶ZnO/ZnMgOヘテロ構造を用いた溶液ゲート電界効果トランジスターのバイオセンシング特性 (2011)
  • Author(s): 野上隆弘(代表名)
  • Organizer: 第58回応用物理学関係連合講演会
  • Place of Presentation: 神奈川工科大学(神奈川県)
  • Year and Date: 2011-03-25
• [Presentation] バイオセンサ応用に向けた酸化亜鉛系イオン感応トランジスターの開発 (2010)
  • Author(s): 小池一歩,辻久美穂,野上隆弘,尾形健一,佐々誠彦,井上正崇,矢野満明
  • Organizer: 薄膜材料デバイス研究会第7回研究集会
  • Place of Presentation: 奈良100年会館
  • Year and Date: 2010-11-06
• [Presentation] バイオセンサ応用に向けた酸化亜鉛系イオン感応トランジスタの開発 (2010)
  • Author(s): 小池一歩(代表名)
  • Organizer: 薄膜材料デバイス研究会 第7回研究集会
  • Place of Presentation: 奈良100年会館(奈良県)(招待講演)
  • Year and Date: 2010-11-06
• [Presentation] M. Yano, Characteristics of microscale ion-sensitive ZnO/ZnMgO field-effect transistors formed on glass substrates (2010)
  • Author(s): K. Tsuji, T. Nogami, K. Koike, K. Ogata, S. Sasa, M. Inoue
  • Organizer: 29th Electronic Materials Sympo.
  • Place of Presentation: Shizuoka
  • Year and Date: 2010-07-14
• [Presentation] Characterization of microscale ion-sensitive ZnO/ZnMgO field-effect transistors for med on glass substrates (2010)
  • Author(s): 辻久美穂(代表名)
  • Organizer: 29th Electronic Materials Symposium
  • Place of Presentation: 伊豆,ラフォーレ修善寺(静岡県)
  • Year and Date: 2010-07-14
• [Presentation] Micro-fabrication and characterization of an ion-sensitive ZnO-based transistor on a glass substrate (2010)
  • Author(s): K. Tsuji, K. Koike, K. Ogata, S. Sasa, M. Inoue, M. Yano
  • Organizer: 2010 Int. Meetingfor Future of Electron Devices
  • Place of Presentation: kansai, kansai University
  • Year and Date: 2010-05-13
• [Presentation] Growth and device application of zinc oxide (2010)
  • Author(s): 佐々誠彦(代表名)
  • Organizer: 2010 Int.Meeting for Future of Electron Devices
  • Place of Presentation: 関西大学(大阪府)
  • Year and Date: 2010-05-13
• [Presentation] Micro-fabrication and characterization of an ion-sensitive ZnO-based transistor on a glass substrate (2010)
  • Author(s): 辻久美穂(代表名)
  • Organizer: 2010 Int.Meeting for Future of Electron Devices
  • Place of Presentation: 関西大学(大阪府)
  • Year and Date: 2010-05-13
• [Presentation] ガラス基板上へのイオン感応性酸化亜鉛トランジスターの作製と評価 (2010)
  • Author(s): 辻久美穂,野上隆弘,小池一歩,尾形健一,佐々誠彦,井上正崇,矢野満明
  • Organizer: 日本材料学会半導体エレクトロニクス部門,平成22年度第1回研究会
  • Place of Presentation: 大阪大学
  • Year and Date: 2010-05-08
• [Presentation] ガラス基板上へのイオン感応性酸化亜鉛トランジスターの作製と評価 (2010)
  • Author(s): 辻久美穂(代表名)
  • Organizer: 日本材料学会半導体エレクトロニクス部門研究会
  • Place of Presentation: 大阪大学(大阪府)
  • Year and Date: 2010-05-08
• [Presentation] ZnOナノロッドへの酵素固定化とグルコースセンシング (2010)
  • Author(s): 土橋秀章(代表名)
  • Organizer: 日本材料学会半導体エレクトロニクス部門研究会
  • Place of Presentation: 大阪大学(大阪府)
  • Year and Date: 2010-05-08
• [Book] 酸化亜鉛の最先端技術と将来 (2011)
  • Author(s): 小池一歩
  • Publisher: シーエムシー出版
• [Book] 酸化亜鉛の最先端技術と将来,監修:山本哲也,6章2節「バイオセンサー」執筆 (2011)
  • Author(s): 小池一歩(6章2節 第一著者)
  • Publisher: シーエムシー
• [Remarks]
  • URL: http://www.oit.ac.jp/elc/~koike/
• [Remarks] 研究代表者の研究室HP
  • URL: http://www.oit.ac.jp/elc/~koike/
• [Remarks] 研究代表者が所属する研究センターHP
  • URL: http://www.oit.ac.jp/japanese/nanotech/
• [Remarks]
  • URL: http://www.oit.ac.jp/elc/~koike/