Biosensors based on graphene field-effect transistors

• Project/Area Number: 22760541
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Structural/Functional materials
• Research Institution: Osaka University
• Principal Investigator: OHNO Yasuhide 大阪大学, 産業科学研究所, 助教 (90362623)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2010: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: グラフェン / 電界効果トランジスタ / バイオセンサ / イオンセンサ / 抗原抗体反応 / 電気二重層 / フラグメント抗体 / バイオセンサー / アブタマー / 免疫センサー

Research Abstract

Biosensing applications based on graphene field-effect transistors were investigated. Solution pH can be detected with the resolution of 0. 025 using the graphene devices. Although the antibodies cannot be used for FET-based biosensors due to the thickness of the electrical double layer, we applied the aptamer and fragment antigen-binding. The results show that the graphene field-effect transistors have high potentials for the biosensors.

Research Products

• [Journal Article] Immunosensors Based on Graphene Field-Effect Transistors using Antigen-Binding Fragments (2012)
  • Author(s): S. Okamoto, Y. Ohno, K. Maehashi, K. Inoue, and K. Matsumoto
  • Journal Title: Jpn. J. Appl. Phys. Volume: Vol.51(in press)
• [Journal Article] Immunosensors Based on Graphene Field-Effect Transistors using Antigen-Binding Fragments (2012)
  • Author(s): 岡本翔伍、大野恭秀
  • Journal Title: Japanese Journal of Applied Physics Volume: 51(印刷中)
  • Peer Reviewed
• [Journal Article] Label-Free Aptamer-Based Immunoglobulin Sensors Using Graphene Field-Effect Transistors (2011)
  • Author(s): Y. Ohno, K. Maehashi, K. Inoue, and K. Matsumoto
  • Journal Title: Jpn. J. Appl. Phys. Volume: Vol.50, No.7 Pages: 70120-70120
  • NAID: 210000070803
  • Peer Reviewed
• [Journal Article] Highly Sensitive Electrical Detection of Sodium Ions Based on Graphene Field-Effect Transistors (2011)
  • Author(s): Y. Sofue, Y. Ohno, K. Maehashi, K. Inoue, and K. Matsumoto
  • Journal Title: Jpn. J. Appl. Phys. Volume: Vol.50, No.6
  • NAID: 210000070675
  • Peer Reviewed
• [Journal Article] Highly Sensitive Electrical Detection of Sodium Ions Based on Graphene Field-Effect Transistors (2011)
  • Author(s): 祖父江靖之、大野恭秀
  • Journal Title: Japanese Journal of Applied Physics Volume: 50 Issue: 6S Pages: 06GE07-06GE07
  • DOI: 10.1143/jjap.50.06ge07
  • NAID: 210000070675
  • Peer Reviewed
• [Journal Article] Label-Free Aptamer-Based Immunoglobulin Sensors Using Graphene Field-Effect Transistors (2011)
  • Author(s): 大野恭秀
  • Journal Title: Japanese Journal of Applied Physics Volume: 50 Issue: 7R Pages: 70120-70120
  • DOI: 10.1143/jjap.50.070120
  • NAID: 210000070803
  • Peer Reviewed
• [Journal Article] Label-Free Biosensors Based on Aptamer-Modified Graphene Field-Effect Transistors (2010)
  • Author(s): Y. Ohno, K. Maehashi, and K. Matsumoto
  • Journal Title: J. Am. Chem. Soc. Volume: Vol.132, No.51 Pages: 18012-18013
  • Peer Reviewed
• [Journal Article] Chemical and biological sensing application based on graphene field-effect transistors (2010)
  • Author(s): Y. Ohno, K. Maehashi, and K. Matsumoto
  • Journal Title: Biosens. Bioelectron. Volume: Vol.26, No.4 Pages: 1727-1730
  • Peer Reviewed
• [Journal Article] Chemical and biological sensing application based on graphene field-effect transistors (2010)
  • Author(s): 大野恭秀
  • Journal Title: Biosensers and Bioelectronics Volume: 26 Pages: 1727-1730
  • Peer Reviewed
• [Journal Article] Label-Free Biosensors Based on Aptamer-Modified Graphene Field-Effect Transistors (2010)
  • Author(s): 大野恭秀
  • Journal Title: Journal of the American Chemical Society Volume: 132 Pages: 18012-18013
  • Peer Reviewed
• [Presentation] Chemical and Biological Sensors Using Graphene Field-Effect Transistors (2011)
  • Author(s): Y. Ohno
  • Organizer: TeraNano PIRE Kick-Off Meeting 2011
  • Place of Presentation: Houston, USA
  • Year and Date: 2011-10-07
• [Presentation] フラグメント抗体-抗原反応を利用したグラフェンFETバイオセンサ (2011)
  • Author(s): 大野恭秀
  • Organizer: 第72回応用物理学会学術講演会
  • Place of Presentation: 山形大学(日本)
  • Year and Date: 2011-08-30
• [Presentation] Graphene field-effect transistors for label-free chemical and biological sensors (2011)
  • Author(s): Y. Ohno
  • Organizer: 2011 SPIE Defense Security+ Sensing
  • Place of Presentation: Orlando, USA
  • Year and Date: 2011-04-28
• [Presentation] Graphene field-effect transistors for label-free chemical and biological sensors (2011)
  • Author(s): 大野恭秀
  • Organizer: 2011 SPIE Defense Security+Sensing
  • Place of Presentation: Orlando World Center Marriott (米国)(招待講演)
  • Year and Date: 2011-04-28
• [Presentation] Label-free Aptamer-Based Immunosensors using Graphene Field-Effect Transistors (2010)
  • Author(s): 大野恭秀
  • Organizer: 23rd International Microprocesses and Nanotechnology Conference
  • Place of Presentation: リーガロイヤル小倉
  • Year and Date: 2010-11-11
• [Presentation] Label-free Aptamer-Based Immunosensors using Graphene Field-Effect Transistors (2010)
  • Author(s): Y. Ohno
  • Organizer: 23rd International Microprocesses and Nanotechnology Conference
  • Place of Presentation: 小倉
  • Year and Date: 2010-11-10
• [Presentation] Graphene Field-Effect Transistors for Label-Free Biological Sensors (2010)
  • Author(s): 大野恭秀
  • Organizer: IEEE Sensors 2010 Conference
  • Place of Presentation: Hilton Waikoloa Village (USA)(招待講演)
  • Year and Date: 2010-11-02
• [Presentation] Graphene Field-Effect Transistors for Label-Free Biological Sensors (2010)
  • Author(s): Y. Ohno
  • Organizer: IEEE Sensors 2010 Conference
  • Place of Presentation: Waikoloa, USA
  • Year and Date: 2010-11-01
• [Presentation] Chemical-and Bio-sensors Based on Graphene Field-Effect Transistors (2010)
  • Author(s): Y. Ohno
  • Organizer: International Symposium on Graphene Devices : Technology, Physics, and Modeling
  • Place of Presentation: 仙台
  • Year and Date: 2010-10-27
• [Presentation] Chemical- and Bio-sensors Based on Graphene Field-Effect Transistors (2010)
  • Author(s): 大野恭秀
  • Organizer: International Symposium on Graphene Devices : Technology, Physics, and Modeling
  • Place of Presentation: 東北大学
  • Year and Date: 2010-10-27
• [Presentation] Label-Free Immunosensors Based on Aptamer-Modified Graphene Field-Effect Transistors (2010)
  • Author(s): Y. Ohno
  • Organizer: 2010 International Conference on Solid State Device and Materials
  • Place of Presentation: 東京
  • Year and Date: 2010-09-23
• [Presentation] Label-Free Immunosensors Based on Aptamer-Modified Graphene Field-Effect Transistors (2010)
  • Author(s): 大野恭秀
  • Organizer: 2010 International Conference on Solid State Device and Materials
  • Place of Presentation: 東京大学
  • Year and Date: 2010-09-23
• [Presentation] Electrical detection of biomolecules based on graphene field-effect transistors (2010)
  • Author(s): Y. Ohno
  • Organizer: 20th Anniversary World Congress on Biosensors
  • Place of Presentation: Glasgow, UK
  • Year and Date: 2010-05-27
• [Presentation] Electrical detection of biomolecules based on graphene field-effect transistors (2010)
  • Author(s): 大野恭秀
  • Organizer: 20th Anniversary World Congress on Biosensors
  • Place of Presentation: Scottish Exhibition and Conference Center (UK)
  • Year and Date: 2010-05-27
• [Book] Physics and Applications of Graphene (2011)
  • Author(s): Y. Ohno, K. Maehashi, and K. Matsumoto, Intech
  • Publisher: Experiments
• [Book] Physics and Applications of Graphene-Experiments (2011)
  • Author(s): 大野恭秀
  • Publisher: INTECH