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Creation of artificial cell clock devices by the biological clock element

Research Project

Project/Area Number 22760604
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biofunction/Bioprocess
Research InstitutionNagoya University

Principal Investigator

KOJIMA Masaru  名古屋大学, 工学研究科, 特任助教 (00533647)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords生物物理 / 生物・生体工学 / ナノバイオ / 分子機械 / 生体機能利用
Research Abstract

We encapsulated nano-sized clock protein KaiA, KaiB, KaiC, which are elements derived from the biological clock of cyanobacteria, in phospholipid-coated microdroplets. And then, we have successfully detected its activity. As a result, the period length became 35 hr. From the observation of protein localization by fluorescence-label, it is suggested that this long-period was caused by Kai protein localization.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (8 results)

All 2012 2011 2010

All Presentation (8 results)

  • [Presentation] Control of Biological Clock Activity Capsulated by Lipid-mono-layer2012

    • Author(s)
      小嶋勝
    • Organizer
      International Conference on Robots and Automation
    • Place of Presentation
      アメリカ・セントポール
    • Year and Date
      2012-05-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Control of Biological Clock Activity Capsulated by Lipid-mono-layer2012

    • Author(s)
      小嶋勝
    • Organizer
      2012 IEEE International Conference on Robots and Automation
    • Place of Presentation
      アメリカ・セントポール(発表確定)
    • Year and Date
      2012-05-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evaluation of Biological Clock Activity Capsulated by Lipid Mono Layer2011

    • Author(s)
      小嶋勝
    • Organizer
      International Conference on Intelligent Robots and Systems
    • Place of Presentation
      アメリカ・サンフランシスコ
    • Year and Date
      2011-09-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Evaluation of Biological Clock Activity Capsulated by Lipid Mono Layer2011

    • Author(s)
      小嶋勝
    • Organizer
      2012 IEEE/RSJ International Conference on Intelligent Robots and Systems
    • Place of Presentation
      アメリカ・サンフランシスコ
    • Year and Date
      2011-09-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] リン脂質被覆小胞にカプセル化された生物時計活性の評価2011

    • Author(s)
      小嶋勝
    • Organizer
      ナノ・バイオメディシンシンポジウム
    • Place of Presentation
      名古屋大学野依学術交流館
    • Year and Date
      2011-02-21
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Reconstitution of Biological Clock into Microdroplet2010

    • Author(s)
      小嶋勝
    • Organizer
      第48回日本生物物理学会
    • Place of Presentation
      東北大学川内キャンパス
    • Year and Date
      2010-09-21
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Evaluation of Nano Biological Clock Activity Capsulated by Lipid Layer2010

    • Author(s)
      小嶋勝
    • Organizer
      International Conference on Nanotechnology
    • Place of Presentation
      韓国ソウルKINTEX
    • Year and Date
      2010-08-18
    • Related Report
      2011 Final Research Report
  • [Presentation] Evaluation of Nano Biological Clock Activity Capsulated by Lipid Layer2010

    • Author(s)
      小嶋勝
    • Organizer
      IEEE- 10th International Conference on Nanotechnology
    • Place of Presentation
      韓国 ソウル KINTEX
    • Year and Date
      2010-08-18
    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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