| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
We have tried to develop an efficient peptide drug discovery system utilizing highly specific tag-mediated protein immobilization technique. Two cancer-related proteins, FOXP3 and NFkB(p50), were adopted as targets and site specific inhibitory peptides were screened from T7 phage random peptide library. The clear correlation between effective isolation of candidate peptides and pretreatment of phage library with solid substrate for protein immobilization was found. In addition, a number of functional inhibitory peptides with high binding affinity with target proteins were successfully obtained.
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