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Application of enzymatically gellable gelatin derivative to peritoneal dissemination treatment

Research Project

Project/Area Number 22760610
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biofunction/Bioprocess
Research InstitutionOsaka University

Principal Investigator

SAKAI Shinji  大阪大学, 大学院・基礎工学研究科, 准教授 (20359938)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords酵素 / ハイドロゲル / 腹膜播種 / ガン / ガン治療 / ゲル / ゼラチン
Research Abstract

We evaluated the possibility of gelatin derivative possessing phenolic hydroxyl moieties gellable via a horseradish peroxidase-catalyzed reaction as a candidate for controlled release of anti-cancer drugs for the treatment of peritoneal dissemination. Our studies revealed that the hydrogel was not suitable for the purpose. Therefore, we attempted to develop novel biodegradable and in situ gellable hydrogels. The promising hydrogel we developed in this study was the derivative of amylopectin. The aqueous solution of the amylopectin derivative possessing phenolic hydroxyl moieties could be gellable through the horseradish peroxidase-catalyzed reaction. An attractive property of the hydrogel was the degradability in the presence of serum. In addition, we could develop a novel hydrogelation process triggered by glucose using glucose oxidase for supplying hydrogen peroxide for the hydrogelation process.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2012 2011 2010 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (6 results) Remarks (2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Multicellular tumor spheroid formation in duplex microcapsules for anaylsis of chemosensitivity2012

    • Author(s)
      Sakai S, Inamoto K, Liu Y, Tanaka S, Arii S, Taya M
    • Journal Title

      Cancer Science

      Volume: 103 Pages: 549-554

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Glucose-triggered co-enzymatic hydrogelation of aqueous polymer solutions2012

    • Author(s)
      Sakai S, Komatani K, Taya M
    • Journal Title

      RSC Advances

      Volume: 2 Pages: 1502-1507

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] On-demand serum-degradable amylopectin-based in situ gellable hydrogel2012

    • Author(s)
      Sakai S, Liu Y, Matsuyama T, Kawakami K, Taya M
    • Journal Title

      Journal of Materials Chemistry

      Volume: 22 Pages: 1944-1949

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of porous alginate-based scaffolds covalently cross-linked through a peroxidase-catalyzed reaction2011

    • Author(s)
      Sakai S, Kawakami K
    • Journal Title

      Journal of Biomaterials Science

      Volume: 22 Pages: 2407-2416

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hematin is an alternative catalyst to horseradish peroxidase for in situ hydrogelation of polymers with phenolic hydroxyl groups in vivo2010

    • Author(s)
      Sakai S, Moriyama K, Taguchi K, Kawakami K
    • Journal Title

      Biomacromolecules

      Volume: 11 Pages: 2179-2183

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapidly serum-degradable hydrogel templating fabrication of spherical tissues and curved tubular structures

    • Author(s)
      Sakai S, Inagaki H, Liu Y, Matsuyama T, Kihara T, Miyake J, Kawakami K, Taya M
    • Journal Title

      Biotechnology and Bioengineering

      Volume: (印刷中)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] チロシンタグ導入タンパク質/フェノール性水酸基含有ヒドロゲル融合基材の開発2012

    • Author(s)
      境慎司, 足立辰弥, 南畑孝介, 後藤雅宏, 神谷典穂, 川上幸衛, 田谷正仁
    • Organizer
      化学工学会第77年会
    • Place of Presentation
      工学院大学(東京都)
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of in situ gellable and fast degradable hydrogel under the existence of serum for cell-enclosing microcapsule2011

    • Author(s)
      Inagaki H, Sakai S, Matsuyama T, Liu Y, Kawakami K, Taya M
    • Organizer
      XIX International Conference on Bioencapsulation
    • Place of Presentation
      Amboise(France)
    • Year and Date
      2011-10-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 血清と接触すると速やかに溶解する酵素架橋ヒドロゲルの開発とその応用2011

    • Author(s)
      境慎司, 劉揚, 松山智洋, 川上幸衛, 田谷正仁
    • Organizer
      日本生物工学会2011年年会
    • Place of Presentation
      東京農工大学(東京)
    • Year and Date
      2011-09-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 増殖因子と脂肪幹細胞を含む多糖誘導体溶液の体内でのグル化による血管含有組織構築2011

    • Author(s)
      境慎司, 大串裕子, 川上幸衛
    • Organizer
      化学工学会2010年度年会
    • Place of Presentation
      東京農工大学(東京都)
    • Year and Date
      2011-03-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] 酵素による架橋と分解を利用する材料設計と足性医療技術への適用2010

    • Author(s)
      境慎司, 田谷正仁, 川上幸衛
    • Organizer
      化学工学会2010年秋季大会
    • Place of Presentation
      同志社大学(京都)
    • Year and Date
      2010-09-06
    • Related Report
      2011 Final Research Report
  • [Presentation] 酵素による架橋と分解を利用する材料設計と再生医療用技術への適用2010

    • Author(s)
      境慎司, 田谷正仁, 川上幸衛
    • Organizer
      化学工学会2010年度秋季大会
    • Place of Presentation
      同志社大学(京都府)
    • Year and Date
      2010-09-06
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.cheng.es.osaka-u.ac.jp/tayalabo/tumor.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.cheng.es.osaka-u.ac.jp/tayalabo/sakai/

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] ヒドロゲルの製造方法2011

    • Inventor(s)
      境慎司, 駒谷季実子, 田谷正仁
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      2011-023145
    • Filing Date
      2011-02-04
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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