| Project/Area Number |
22760615
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Biofunction/Bioprocess
|
|---|
| Research Institution | National Institute for Materials Science |
|---|
Principal Investigator |
YAMAZAKI Tomohiko 独立行政法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, MANA研究者 (50419264)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 分子認識 / 酵素 / 両親媒性蛋白質 / ハイドロフォビン / マイクロ粒子 / 徐放制御 / ソルターゼ / 分子認識ペプチド |
|---|
| Research Abstract |
We constructed self-assembled membranes and particles using amphipathic protein, hydrophobins. We, then, established the enzyme based anchoring methods to connect biological molecules, such as DNA aptamer, peptide and protein, with amphipathic protein-based self-assembly membrane and particle. The system can be utilized for construction protein microsphere having molecular recognition ability. Furthermore, this protein based microsphere can be applied for an active drug release system induced by biomarker molecule in human body.
|
