Analysis of molecular mechanism in H2A. Z replacement

• Project/Area Number: 22770002
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Genetics/Genome dynamics
• Research Institution: 公益財団法人がん研究会 (2011); The University of Tokyo (2010)
• Principal Investigator: TANABE Masahiko 公益財団法人がん研究会, 有明病院乳腺外科, 医員 (30572333)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: ゲノム機能・発現 / ヒストンバリアント / H2A. Z / エピゲノム / ショウジョウバエ / 乳癌 / ヒストン

Research Abstract

We performed genetical screening by use of Drosophila system to identify the new factors which would reveal the molecular function of H2A. Z. We identified several genes. It was suggested that one of them would co-localize with H2A. Z on promoter area of genes.