Analysis of the X chromosome inactivation-reactivation cycle throughout the mouse life cycle
| Project/Area Number |
22770010
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SUGIMOTO Michihiko 独立行政法人理化学研究所, 動物変異動態解析技術開発チーム, 開発研究員 (10373317)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | X染色体不活性化 / マウス / 初期胚発生 / エピジェネティクス / 初期発生 / DNAメチル化 / 始原生殖細胞 |
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| Research Abstract |
It is known that the X chromosome of female mammals shows inactivation-reactivation cycles throughout the life cycle, especially at the peri-implantation stage, the changes of the X chromosome activity occur during short period. In this study, it was indicated that the re-inactivation of the X chromosome in the epiblast, the future embryo proper, occurs just after implantation. Furthermore, the dynamics of the DNA methylation of the inactive X linked genes during the X reactivation in primordial germ cells was elucidated.
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Report
(3 results)
Research Products
(12 results)
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[Journal Article] Impeding Xist expression from the active X chromosome improves mouse somatic cell nuclear transfer2010
Author(s)
Inoue K., Kohda T., Sugimoto M., Sado T., Ogonuki N., Matoba S., Shiura H., Ikeda R., Mochida K., Fujii T., Sawai K., Otte A. P., Tian C., Yang X., Ishino F., Abe K. and Ogura A.
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Journal Title
Science
Volume: 330
Pages: 496-499
Related Report
Peer Reviewed
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