| Project/Area Number |
22770010
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SUGIMOTO Michihiko 独立行政法人理化学研究所, 動物変異動態解析技術開発チーム, 開発研究員 (10373317)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | X染色体不活性化 / マウス / 初期胚発生 / エピジェネティクス / 初期発生 / DNAメチル化 / 始原生殖細胞 |
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| Research Abstract |
It is known that the X chromosome of female mammals shows inactivation-reactivation cycles throughout the life cycle, especially at the peri-implantation stage, the changes of the X chromosome activity occur during short period. In this study, it was indicated that the re-inactivation of the X chromosome in the epiblast, the future embryo proper, occurs just after implantation. Furthermore, the dynamics of the DNA methylation of the inactive X linked genes during the X reactivation in primordial germ cells was elucidated.
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