Elucidation of mechanisms of selective peroxisome degradation using an ubiquitin-like autophagy protein

• Project/Area Number: 22770049
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Plant molecular biology/Plant physiology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: YOSHIMOTO Koki 独立行政法人理化学研究所, 植物免疫研究グループ, 研究員 (40399316)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: オートファジー / 液胞 / オルガネラ / ペルオキシソーム / 細胞内自己分解 / 品質管理 / タンパク質分解 / 老化

Research Abstract

Autophagy is the major system responsible for the degradation of organelles and cytosolic macromolecules in the vacuole. I found that dysfunctional peroxisomes were highly accumulated in leaves of autophagy-defective mutants, indicating that autophagy is involved in quality control of leaf peroxisomes in plants. I also tried to elucidate molecular mechanisms for selective peroxisome degradation in Arabidopsis.

Research Products

• [Journal Article] Physiological roles of autophagy in plants : Does plant autophagy have a pro-death function? (2010)
  • Author(s): Yoshimoto, K.
  • Journal Title: Plant Signaling & Behavior Volume: 5 Pages: 494-496
  • Peer Reviewed
• [Journal Article] Autophagy in plants and phytopathogens (2010)
  • Author(s): Yoshimoto, K., Takano, Y., and Sakai, Y.
  • Journal Title: FEBS Let. Volume: 584 Pages: 1350-1358
  • Peer Reviewed
• [Journal Article] Role of chloroplasts and other plastids in ageing and death of plants and animals : A tale of Vishnu and Shiva (2010)
  • Author(s): van Doorn, W. G., and Yoshimoto, K.
  • Journal Title: Aging Res Rev. Volume: 9 Pages: 117-130
  • Peer Reviewed
• [Journal Article] The Rab GTPase RabG3b functions in autophagy and contributes to tracheary element differentiation in Arabidopsis (2010)
  • Author(s): Kwon, S. I., Cho, H. J., Jung, J. H., Yoshimoto, K., Shirasu, K., and Park, O.
  • Journal Title: Plant J. Volume: 64 Pages: 151-164
  • Peer Reviewed
• [Journal Article] 植物におけるオートファジー研究の展開 (2010)
  • Author(s): 吉本光希
  • Journal Title: 植物の生長調節 Volume: 45 Pages: 24-32
  • NAID: 110007641950
• [Journal Article] The Rab GTPase RabG3b functions in autophagy and contributes to tracheary element differentiation in Arabidopsis. (2010)
  • Author(s): Kwon, S., et al.
  • Journal Title: Plant J. Volume: 64 Pages: 151-164
  • Peer Reviewed
• [Journal Article] Autophagy in plants and phytopathogens. (2010)
  • Author(s): Yoshimoto, K., et al.
  • Journal Title: FEBS Let. Volume: 584 Pages: 1350-1358
  • Peer Reviewed
• [Journal Article] Role of chloroplasts and other plastids in ageing and death of plants and animals : A tale of Vishnu and Shiva. (2010)
  • Author(s): Van Doom, W.G., et al.
  • Journal Title: Aging Res.Rev. Volume: 9 Pages: 117-130
  • Peer Reviewed
• [Presentation] 日本植物生理学会奨励賞:植物における細胞内自己分解システム・オートファジーの分子機構とその生理機能に関する研究 (2012)
  • Author(s): 吉本光希
  • Organizer: 日本植物生理学会年会
  • Place of Presentation: 京都
  • Year and Date: 2012-03-17
• [Presentation] 日本植物生理学会奨励賞:植物における細胞内自己分解システム・オートファジーの分子機構とその生理機能に関する研究 (2012)
  • Author(s): 吉本光希
  • Organizer: 第53回日本植物生理学会年会
  • Place of Presentation: 京都府(招待講演)
  • Year and Date: 2012-03-17
• [Presentation] オートファジーによる緑葉ペルオキシソームの品質管理 (2011)
  • Author(s): 吉本光希,大隅良典,白須賢
  • Organizer: 日本植物学会年会
  • Place of Presentation: 東京
  • Year and Date: 2011-09-17
• [Presentation] オートファジーによる緑葉ペルオキシソームの品質管理 (2011)
  • Author(s): 吉本光希
  • Organizer: 日本植物学会第75回大会
  • Place of Presentation: 東京都
  • Year and Date: 2011-09-17
• [Presentation] 植物オートファジーによる細胞死の制御 (2011)
  • Author(s): 吉本光希,大隅良典,白須賢
  • Organizer: 日本植物生理学会年会
  • Place of Presentation: 仙台
  • Year and Date: 2011-03-22
• [Presentation] 植物オートファジーによる細胞死の制御 (2011)
  • Author(s): 吉本光希
  • Organizer: 第52回日本植物生理学会年会
  • Place of Presentation: 仙台市
  • Year and Date: 2011-03-22
• [Presentation] 老化・病原菌感染時における植物オートファジーの役割 (2010)
  • Author(s): 吉本光希,大隅良典,白須賢
  • Organizer: 日本植物学会年会
  • Place of Presentation: 春日井
  • Year and Date: 2010-09-10
• [Presentation] 老化・病原菌感染時における植物オートファジーの役割 (2010)
  • Author(s): 吉本光希
  • Organizer: 日本植物学会第74回大会
  • Place of Presentation: 春日井市
  • Year and Date: 2010-09-10
• [Presentation] Plant autophagy negatively regulates cell death by controlling salicylic acid signaling during senescence and the innate immune response (2010)
  • Author(s): Yoshimoto, K.
  • Organizer: 21^<st> International Conference on Arabidopsis Research
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 2010-06-07
• [Presentation] Plant autophagy negatively regulates cell death by controlling salicylic acidsignaling during senescence and the innate immune response (2010)
  • Author(s): 吉本光希
  • Organizer: 21^<st> International Conference on Arabidopsis Research
  • Place of Presentation: 横浜市
  • Year and Date: 2010-06-07
• [Presentation] オートファジー能欠損シロイヌナズナにおけるプログラム細胞死の原因は過剰なサリチル酸シグナリングである (2010)
  • Author(s): 吉本光希,大隅良典,白須賢
  • Organizer: 日本植物病理学会年会
  • Place of Presentation: 京都
  • Year and Date: 2010-04-20
• [Presentation] オートファジー能欠損シロイヌナズナにおけるプログラム細胞死の原因は過剰なサリチル酸シグナリングである (2010)
  • Author(s): 吉本光希
  • Organizer: 平成22年度日本植物病理学会大会
  • Place of Presentation: 京都市
  • Year and Date: 2010-04-20