Regional regulation of corticosteroid in teleosts

• Project/Area Number: 22770053
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Morphology/Structure
• Research Institution: The University of Tokyo
• Principal Investigator: KUSAKABE Makoto 東京大学, 大気海洋研究所, 助教 (40451893)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 浸透圧調節 / 鰓 / コルチゾル / コルチコイド受容体 / ステロイド代謝酵素 / 11β-HSD / ニジマス / 大西洋サケ / 11β-水酸化ステロイド脱水素酵素 / 糖質コルチコイド受容体 / 鉱質コルチコイド受容体 / アトランティックサーモン

Research Abstract

Cortisol is a major hormone and known to have multiple effects and also known to be an osomoregulatory hormone in teleosts. However, how fish tissues discriminate between these distinct corticosteroid actions is not clearly understood. The present study showed that levels of cortisol appeared to be locally regulated to the optimal levels by the action of steroidogenic enzymes.

Research Products

• [Presentation] 陸封型および遡河回遊型イトヨにおける塩分耐性の解析 (2011)
  • Author(s): 日下部誠
  • Organizer: 第82回日本動物学会
  • Place of Presentation: 北海道・旭川
  • Year and Date: 2011-09-23
• [Presentation] RELAXIN-3 AND RELAXIN/INSULIN-LIKE FAMILY PEPTIDE RECEPTOR 3 IN RAINBOW TROUT : SITES OF GENE EXPRESSION AND CHANGES IN MESSENGER RNA LEVELS DURING SPERMATOGENESIS IN TESTES (2011)
  • Author(s): 日下部誠
  • Organizer: 11th International Symposium on Reproductive Physiology of Fish
  • Place of Presentation: インド・コーチン
  • Year and Date: 2011-08-11
• [Presentation] Difference in the seawater tolerance of anadromous and stream resident morphs of three-spined stickleback(Gasterosteus aculeatus) (2011)
  • Author(s): 日下部誠,北野潤,石川麻乃
  • Organizer: 第82回日本動物学会大会
  • Place of Presentation: 旭川市大雪クリスタルホール
• [Presentation] Relaxin-3 and relaxin/insulin-like family peptide receptor3 in rainbow trout : sites of gene expresson and changes in mRNA levels during spermatogenesis in testes (2011)
  • Author(s): Makoto Kusakabe, Yoshio Takei, J. Adam Luckenbach
  • Organizer: 9th International Symposium on Reproductive Physiology of Fish
  • Place of Presentation: Lulu International Convention Center and Garden Hotels, India
• [Presentation] サケ科魚類の鰓におけるコルチゾルの代謝調節メカニズム (2010)
  • Author(s): 日下部誠
  • Organizer: 第35回日本比較内分泌学会大会
  • Place of Presentation: グランシップ(静岡県コンベンションアーツセンター)
  • Year and Date: 2010-11-19
• [Presentation] サケ科魚類の鰓におけるコルチゾルの代謝調節メカニズム (2010)
  • Author(s): 日下部誠、Stephen D. McCormick、Graham Young、竹井祥郎
  • Organizer: 第35回日本比較内分泌学会大会及びシンポジウム2010静岡
  • Place of Presentation: 静岡グランシップ