| Project/Area Number |
22770054
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|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
|---|
| Research Field |
Morphology/Structure
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
ARAKAWA Satoko 東京医科歯科大学, 難治疾患研究所, 助教 (90415159)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 微細構造 / オートファジー / 血球分化 / ミトコンドリア / 電子顕微鏡 / オルタナティブ・オートファジー / 赤血球 |
|---|
| Research Abstract |
We provide evidence that mammalian macroautophagy not only involves an ATG5/ATG7-dependent conventional pathway, but also an ATG5/ATG7-independent alternate pathway. In vivo, Atg5-independent alternative macroautophagy was detected in several embryonic tissues(cf. brain, liver, heart). It also had a function in clearing mitochondria during erythroid maturation.
|
