Investigation of the interaction mechanism for multiple presequences by mitochondrial Tom20
| Project/Area Number |
22770104
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Hokkaido University (2012)
Kyushu University (2010-2011) |
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Principal Investigator |
SAITOH Takashi 北海道大学, 大学院・薬学研究院, 技術職員 (00432914)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 分子認識及び相互作用 / 構造生物学 / 蛋白質 / ＮＭＲ / Ｘ線結晶構造解析 / 蛋白質複合体 / X線結晶構造解析 / NMRスペクトル解析 / 相互作用 / NMR / ミトコンドリア |
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| Research Abstract |
In previous study, we proposed that a dynamic equilibrium betweenthe multiple bound states is the molecular mechanism of the broadly selective specificity ofthe Tom20 receptor towards the divergent mitochondrial presequences. In this study, wecarried out X-ray crystal structure analysis and NMR spectroscopy experiments using newcomplexes between Tom20 and presequenses. We attempted to express of full lengthTom20 protein.
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Report
(4 results)
Research Products
(7 results)
