| Project/Area Number |
22770108
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | Yokohama City University |
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Principal Investigator |
TODOKORO Yasuto 横浜市立大学, 生命ナノシステム科学研究科, 特任助教 (00533150)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 核磁気共鳴法 / 固体NMR / 構造生物学 / ヌクレオソーム / ヒストン / クロマチン / 天然変性 |
|---|
| Research Abstract |
In eukaryotic cells the fundamental structural unit of chromatin is a nucleosome core, consisting of two copies of four histones and DNA, whose crystalline structures have been determined. However in the crystals the N-terminal histone tails, which are responsible for gene regulations by their chemical modifications could not be well identified. Here, we have examined the structures of N-terminal histone tails by solid-state NMR and suggested that the histone tails hold flexible random coil structures, which might play significant roles in gene regulations.
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