| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
In the mammalian neuroendocrine system, D-aspartate plays important roles in the regulation of the synthesis and secretion of hormones. PLP-dependent aspartate racemase and FAD-dependent D-aspartate oxidase are the enzymes known to be responsible for the synthesis or the degradation of D-aspartate, respectively. To understand the substrate specificity of these two enzymes we have determined the structures of the following two wild-type enzymes : aspartate racemase from Scapharca broughtonii and D-aspartate oxidase from Yeast Cryptococcus humicola at 2.15 and 2.00Åresolution, respectively.
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