Effect of molecular chaperone on misfolding protein aggregation
| Project/Area Number |
22770117
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Structural biochemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
ZAKO Tamotsu 独立行政法人理化学研究所, 前田バイオ工学研究室, 専任研究員 (50399440)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | アミロイド / 分子シャペロンタンパク質 / ミスフォールディングタンパク質凝集 / プレフォルディン / 可溶性オリゴマー / 細胞毒性 / タンパク質ミスフォールディング病 / アルツハイマー病 / アミロイドβ / タンパク質凝集 |
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| Research Abstract |
Protein misfolding disease, such as Alzheimer's' disease(AD), is caused by misfolded protein aggregates that induce molecular stress and interfere with cellular function. We examined effect of molecular chaperone prefoldin(PFD) on aggregation of amyloid beta and poly glutamine protein that cause AD and Huntington disease, respectively. We found that PFD could inhibit their aggregation in vitro.
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Report
(3 results)
Research Products
(43 results)
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[Journal Article] Bio-Supramolecular Photochirogenesis with Molecular Chaperone : Enantiodifferentiating Photocyclodimerization of 2-Anthracenecarboxylate Mediated by Prefoldin2010
Author(s)
Bando K., Zako T., Sakono M., Maeda M., Wada T., Nishijima M., Fukuhara G., Yang C., Mori T., Pace TCS., Bohne C. and Inoue Y.
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Journal Title
Photochem. & Photobiol. Sci
Volume: 9
Pages: 655-60
Related Report
Peer Reviewed
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[Presentation] Supramolecular photochirogenesis with biomolecular hosts2010
Author(s)
Y. Inoue, M. Nishijima, C. Yang, T. Mori, T. Wada, K. Bando, T. Zako, M. Sakon, M. Maeda, T. Pace, C. Bohne
Organizer
Pacifichem2010
Place of Presentation
Honolulu, USA
Year and Date
2010-12-16
Related Report
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[Presentation] Molecular chaperone prefoldin blocks the formation of mutant Huntingtin oligomer and inclusion body, resulting in reduction of its cytotoxity2010
Author(s)
Erika Tashiro, Hideki Muto, Tamotsu Zako, Makoto Miyazawa, Hirotake Kitaura, Akira Kitamura, Hiroshi Kubota, Mizuo Maeda, Masataka Kinjo, Hiroyoshi Ariga
Organizer
Neuroscience
Place of Presentation
San Diego, USA
Year and Date
2010-11-16
Related Report
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