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Molecular characterization of selective lipid transport using cocoon color genes in the silkworm

Research Project

Project/Area Number 22770138
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Functional biochemistry
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

SAKUDOH Takashi  国立感染症研究所, 放射能管理室, 主任研究官 (70455393)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords膜輸送と輸送タンパク質 / 選択的脂質輸送 / カロテノイド / SR-BI / CD36 / カイコ / 繭色
Research Abstract

The F gene, which controls the transport of beta-carotene from insect hemolymph into the silk gland, encoded SCRB15, a transmembrane protein which belongs to the CD36 superfamily. SCRB15 is paralogous to Cameo2, which is encoded by the C gene, which controls the transport of lutein. Elucidation of the molecular mechanisms for the difference in carotenoid specificity between SCRB15 and Cameo2 will provide mechanistic insights for the selective lipid transport by the CD36 superfamily, which is also important for the transmission of infectious pathogens

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (15 results)

All 2013 2012 2011 2010 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (12 results)

  • [Journal Article] CD36 homolog divergence is responsible for the selectivity of carotenoid species migration to the silk gland of the silkworm Bombyx mori .2013

    • Author(s)
      Sakudoh T, Kuwazaki S, Iizuka T, Narukawa J, Yamamoto K, Uchino K, Sezutsu H, Banno Y, Tsuchida K
    • Journal Title

      Journal of Lipid Research

      Volume: 54(2) Issue: 2 Pages: 482-95

    • DOI

      10.1194/jlr.m032771

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Diversity in copy number and structure of a silkworm morphogenetic gene as a result of domestication.2011

    • Author(s)
      Sakudoh T, Nakashima T, Kuroki Y, Fujiyama A, Kohara Y, Honda N, Fujimoto H, Shimada T, Nakagaki M, Banno Y, Tsuchida K
    • Journal Title

      Genetics

      Volume: 187(3) Issue: 3 Pages: 965-67

    • DOI

      10.1534/genetics.110.124982

    • Related Report
      2012 Final Research Report
  • [Journal Article] Diversity in Copy Number and Structure of a Silkworm Morphogenetic Gene as a Result of Domestication2011

    • Author(s)
      Takashi Sakudoh, Takeharu Nakashima, Yoko Kuroki, Asao Fujiyama, Yuji Kohara, Naoko Honda, Hirofumi Fujimoto, Toru Shimada, Masao Nakagaki, Yutaka Banno, Kozo Tsuchida
    • Journal Title

      Genetics

      Volume: VOL.187 Pages: 965-976

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] 繭色遺伝子CBP の家畜化による構造多様化2012

    • Author(s)
      作道 隆, 中島 健陽, 伴野 豊, 土田 耕三
    • Organizer
      新学術領域研究「複合適応形質進化の遺伝子基盤解明」平成24年度公開 シンポジウム.
    • Place of Presentation
      東京 東京大学
    • Year and Date
      2012-09-26
    • Related Report
      2012 Final Research Report
  • [Presentation] クラスB スカベンジャー受容体相同遺伝子の強制発現による繭の着色2012

    • Author(s)
      作道 隆, 飯塚 哲也, 内野 恵郎, 瀬筒 秀樹, 桑崎 誠剛, 生川 潤子, 山本 公 子, 伴野 豊, 本田 尚子, 藤本 浩文, 土田 耕三
    • Organizer
      第80回蚕糸・昆虫機能利用学術講演会
    • Place of Presentation
      福岡 九州大学
    • Year and Date
      2012-03-18
    • Related Report
      2012 Final Research Report
  • [Presentation] クラスBスカベンジャー受容体相同遺伝子の強制発現による繭の着色2012

    • Author(s)
      作道隆、飯塚哲也、内野恵郎、瀬筒秀樹、桑崎誠剛、生川潤子、山本公子、伴野豊、本田尚子、藤本浩文、土田耕三
    • Organizer
      平成24年度蚕糸・昆虫機能利用学術講演会
    • Place of Presentation
      九州大学(福岡県)
    • Year and Date
      2012-03-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cameo2とCBP発現S2細胞によるルテインの取り込み2012

    • Author(s)
      永山春菜、作道隆、湯浅正志、横山洋、本田尚子、藤本浩文、岩野秀俊、土田耕三
    • Organizer
      平成24年度蚕糸・昆虫機能利用学術講演会
    • Place of Presentation
      九州大学(福岡県)
    • Year and Date
      2012-03-18
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cameo2 とCBP 発現S2 細胞によるルテインの取り込み2012

    • Author(s)
      永山 春菜, 作道 隆, 湯浅 正志, 横山 洋, 本田 尚子, 藤本 浩文, 岩野 秀俊, 土田 耕三
    • Organizer
      第80回蚕糸・昆虫機能利用学術講演会
    • Place of Presentation
      福岡 九州大学
    • Year and Date
      2012-03-08
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular dissection of carotenoid transport system using silkworm mutants defective in cocoon coloration.2010

    • Author(s)
      Sakudoh T, Tsuchida K
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      兵庫 神戸国際展示場
    • Year and Date
      2010-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular dissection of carotenoid transport system using silkworm mutants defective in cocoon coloration2010

    • Author(s)
      Takashi Sakudoh, Kozo Tsuchida
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会(BMB2010)
    • Place of Presentation
      神戸国際展示場(兵庫)
    • Year and Date
      2010-12-07
    • Related Report
      2010 Annual Research Report
  • [Presentation] Molecular genetic analysis of carotenoid pigmentation in silkworm cocoons.2010

    • Author(s)
      Sakudoh T
    • Organizer
      Silkworm Genome Unofficial"KARAOKE" Meeting(有志によるカイコゲノム関連研究集会)
    • Place of Presentation
      茨城 デイズタウン
    • Year and Date
      2010-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Molecular genetic analysis of carotenoid pigmentation in silkworm cocoons2010

    • Author(s)
      Takashi Sakudoh
    • Organizer
      Silkworm Genome Unofficial "KARAOKE" Meeting(有志によるカイコゲノム関連研究集会)
    • Place of Presentation
      デイズタウン(茨城)
    • Year and Date
      2010-11-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] 繭色を支配するカロテノイド結合タンパク質の遺伝子構造は家畜化の過程で大きく多様化した2010

    • Author(s)
      作道 隆, 中島 健陽, 嶋田 透, 伴野 豊, 中島 裕美子, 中垣 雅雄, 高田 直子, 藤本 浩文, 土田 耕三
    • Organizer
      第80回蚕糸・昆虫機能学術講演会
    • Place of Presentation
      長野 信州大学
    • Year and Date
      2010-04-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 繭色を支配するカロテノイド結合タンパク質の遺伝子構造は家畜化の過程で大きく多様化した2010

    • Author(s)
      作道隆, 中島健陽, 嶋田透, 伴野豊, 中島裕美子, 中垣雅雄, 高田直子, 藤本浩文, 土田耕三
    • Organizer
      第80回蚕糸・昆虫機能学術講演会
    • Place of Presentation
      信州大学(長野)
    • Year and Date
      2010-04-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 繭色遺伝子CBPの家畜化による構造多様化

    • Author(s)
      作道 隆、中島 健陽、伴野 豊、土田 耕三
    • Organizer
      新学術領域研究「複合適応形質進化の遺伝子基盤解明」 平成24年度公開シンポジウム
    • Place of Presentation
      東京大学弥生講堂
    • Related Report
      2012 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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