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Structural analysis of Plasmodium falciparummalaria vaccine candidate antigen SERA5

Research Project

Project/Area Number 22770151
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Biophysics
Research InstitutionOsaka University

Principal Investigator

YAGI Masanori  大阪大学, 微生物病研究所, 特任研究員 (60452463)

Project Period (FY) 2010 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsタンパク質の物性 / マラリアワクチン / マラリア / ワクチン / 構造物性 / SE36 / 熱帯熱マラリア / タンパク質の構造安定性
Research Abstract

Phase Ib clinical trial of malaria vaccine candidate SE36 in Uganda showed the safety of SE36 and possible protective effect against symptomatic malaria. However, no information has been reported on tertiary structure and physicochemical properties of SE36. This study revealed that the protective epitopes of SE36 have the characteristics of intrinsically unstructured regions and succeeded in construction of SE36 mutants suitable for structural analysis of SE36 antigen.

Report

(4 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Annual Research Report
  • 2010 Annual Research Report
  • Research Products

    (4 results)

All 2012 2011

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Presentation (3 results)

  • [Journal Article] Geographic differentiation of polymorphism in the Plasmodium falciparum malaria vaccine candidate gene SERA52012

    • Author(s)
      Tanabe K, Arisue N, 他12名
    • Journal Title

      Vaccine

      Volume: 30 Issue: 9 Pages: 1583-1593

    • DOI

      10.1016/j.vaccine.2011.12.124

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] Identification and characterization of protective epitopes in malaria vaccine candidate SE362012

    • Author(s)
      Masanori Yagi
    • Organizer
      The 5th International CVRDC-RIMD Joint Symposium
    • Place of Presentation
      韓国・済州島
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification and characterization of protective epitopes in malaria vaccine candidate SE362011

    • Author(s)
      八木 正典
    • Organizer
      IUMS 2011 Sapporo
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2011-09-09
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification and characterization of protective epitopes in malaria vaccine candidate SE362011

    • Author(s)
      八木正典
    • Organizer
      IUMS 2011 Sapporo
    • Place of Presentation
      札幌市
    • Year and Date
      2011-09-09
    • Related Report
      2011 Annual Research Report

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Published: 2010-08-23   Modified: 2019-07-29  

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