Elucidation of molecular mechanisms of ion-transporter proteins by using difference infrared spectroscopy
Project/Area Number |
22770159
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Biophysics
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Research Institution | Institute for Molecular Science |
Principal Investigator |
FURUTANI Yuji 分子科学研究所, 生命・錯体分子科学研究領域, 准教授 (80432285)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
|
Keywords | 生体膜 / 受容体 / チャンネル / 赤外分光法 / 時間分解計測 / 生体分子 / 蛋白質 / 生物物理 |
Research Abstract |
Ion-transporter proteins, ion channels, and receptors in cell membrane work for production of biological energy, generation of bioelectric signal, and reception of external stimuli, respectively. To investigate the molecular mechanisms of these membrane proteins, we applied several methods of difference infrared spectroscopy on them, which provide structural information of biomolecules in action. The molecular mechanisms of microbial rhodopsins, V-type ATPase, and a potassium ion channel, KcsA, were partly elucidated based on the structural changes detected by our methods.
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Report
(3 results)
Research Products
(58 results)
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[Presentation] FTIR Studies of Membrane Proteins2011
Author(s)
Yuji Furutani
Organizer
The Winter School of Sokendai/Asian CORE Program "Frontiers of Molecular Science-Life, Material, Energy, and Space"
Place of Presentation
岡崎コンファレンスセンター(愛知)
Year and Date
2011-02-21
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