| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Research Abstract |
Ion-transporter proteins, ion channels, and receptors in cell membrane work for production of biological energy, generation of bioelectric signal, and reception of external stimuli, respectively. To investigate the molecular mechanisms of these membrane proteins, we applied several methods of difference infrared spectroscopy on them, which provide structural information of biomolecules in action. The molecular mechanisms of microbial rhodopsins, V-type ATPase, and a potassium ion channel, KcsA, were partly elucidated based on the structural changes detected by our methods.
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