Analysis of crosstalk between DNA repair and gene expression control
| Project/Area Number |
22770171
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Molecular biology
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| Research Institution | Osaka University |
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Principal Investigator |
NARITA Takashi 大阪大学, 生命機能研究科, 助教 (50437399)
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| Research Collaborator |
KOH Dawn xin ping 大阪大学, 生命機能研究科, 大学院生
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | DNA修復 / 発現制御 / 転写 / 遺伝情報発現制御 / 遺伝子発現制御 |
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| Research Abstract |
The aim of this study is to investigate the crosstalk between DNA repair factors and transcription factors so that genetic disorders caused by defects in DNA repair system can be understood at a molecular level. The results show that XPG, which is involved in nucleotide excision repair, interacts with some transcription factors as well as general transcription factor TFIIH, and that the function of XPG in transcription is closely related to clinical features found in XP-G patients.
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Report
(3 results)
Research Products
(4 results)
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[Journal Article] MMXD, a TFIIH-independent XPD-MMS19 protein complex involved in chromosome segregation2010
Author(s)
Shinsuke Ito, Li-Jing Tan, Daisuke Andoh, Takashi Narita, Mineaki Seki, Yasuhiro Hirano, Keiko Narita, Isao Kuraoka, Yasushi Hiraoka, Kiyoji Tanaka
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Journal Title
Mol. Cell
Volume: 39
Pages: 632-640
DOI
Related Report
Peer Reviewed
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