| Budget Amount *help |
¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Research Abstract |
In fission yeast, it is thought that the incorporation of CENP-A at G2 phase may act as a rescue of the cell lethality. To identify factors that involved in the G2-loading pathway , we screened for multicopy suppressors of G2-loading deficient cells.Five candidate genes are isolated, and one of them has RNA binding motifs. A double mutant lacking both this RNA binding motif and ams2 genes exhibits synthetic lethality. In this study suggest that the factor may be important in centromere deposition of CENP-A at G2 phase.
|
