Studies on the molecular mechanism of biogenesis and maturation of melanosomes regulated by a novel Rab32/38-binding protein
Project/Area Number |
22770183
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Cell biology
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2010 – 2011
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Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | Rab / Varp / メラノソーム / 膜輸送 / チロシナーゼ / エフェクター / Tyrp1 |
Research Abstract |
Rab GTPases constitute a family of small GTPases that regulate a variety of membrane trafficking events in all eukaryotic cells by recruiting their specific effector molecules. It has been reported that Rab27A, Rab32, and Rab38 are localized on the melanosomes, however, little is known about the function(s)of Rab32/38 in melanocytes. We found a novel mechanism that underlies the transport of melanogenic enzymes to melanosomes regulated by Rab32/38 and Varp that is an effector molecule of Rab32/38.
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] he recycling endosome protein Rab17 regulates melanocytic filopodia formation and melanosome trafficking2011
Author(s)
Beaumont, K. A., Hamilton, N. A., Moores, M. T., Brown, D. L., Ohbayashi, N., Cairncross, O., Cook, A. L., Smith, A. G., Misaki, R., Fukuda, M., Taguchi, T., Sturm, R. A., and Stow, J. L.
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Journal Title
Traffic
Volume: 12
Pages: 627-643
Related Report
Peer Reviewed
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[Journal Article] Functional characterization of two RAB27A missense mutations found in Griscelli syndrome type 22010
Author(s)
Ohbayashi, N., Mamishi, S., Ishibashi, K., Maruta, Y., Pourakbari, B., Tamizifar, B., Mohammadpour, M., Fukuda, M., and Parvaneh, N.
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Journal Title
Pigment Cell Melanoma Res
Volume: 23
Pages: 365-374
Related Report
Peer Reviewed
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[Journal Article] Comprehensive screening for novel Rab-binding proteins by GST pull-down assay using 60 different mammalian Rabs2010
Author(s)
Kanno, E., Ishibashi, K., Kobayashi, H., Matsui, T., Ohbayashi, N. & Fukuda, M
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Journal Title
Traffic
Volume: 11
Issue: 4
Pages: 491-507
DOI
Related Report
Peer Reviewed
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[Journal Article] Comprehensive screening for novel rab-binding proteins by GST pull-down assay using 60 different mammalian Rabs.2010
Author(s)
Kanno, E., Ishibashi, K., Kobayashi, H., Matsui, T., Ohbayashi, N., Fukuda, M.
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Journal Title
Traffic
Volume: 11
Pages: 491-507
Related Report
Peer Reviewed
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[Journal Article] Functional characterization of two RAB27A missense mutations found in Griscelli syndrome type 2.2010
Author(s)
Ohbayashi, N., Mamishi, S., Ishibashi, K., Maruta, Y., Pourakbari, B., Tamizifar, B., Mohammadpour, M., Fukuda, M., Parvaneh, N.
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Journal Title
Pigment Cell Melanoma Res
Volume: 23
Pages: 365-374
Related Report
Peer Reviewed
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