| Project/Area Number |
22770185
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | Chiba University |
|---|
Principal Investigator |
TAKANO Kazunori 千葉大学, 大学院・融合科学研究科, 助教 (60466860)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 細胞骨格 / 運動 / 細胞骨格・運動 / シグナル伝達 / 筋原線維形成 / アクチン重合 / 筋肥大 / 細胞・組織 / 筋原繊維形成 |
|---|
| Research Abstract |
Actin filament is required for cell shape and formation of myofibril, which is contractile apparatus in striated muscle. However, the mechanism how myofibril is built during skeletal muscle hypertrophy remains obscure. In this study, not only it revealed a novel mechanism of actin filament formation at the Z-band by nebulin complex, but also the mechanism was essential for physiological skeletal muscle hypertrophy. Furthermore, this study suggested a possibility that the novel mechanism of actin filament formation might be involved in cardiac hypertrophy leading to heart failure.
|
