Microtubule regulation by polyglycylation
| Project/Area Number |
22770191
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Kitasato University (2012-2013)
Hamamatsu University School of Medicine (2010-2011) |
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Principal Investigator |
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| Project Period (FY) |
2010-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 微小管 / 翻訳後修飾 / アクチン細胞骨格 / 細胞極性 / シグナル伝達 / 細胞骨格 / アクチン繊維 / 細胞運動 / ポリグリシン化 |
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| Research Abstract |
Cytoskeleton is crucial for cell morphology and cell polarity. I have studied (1) the role of polyglycylation of tubulin and (2) a novel regulatory mechanism of FilGAP, key regulator of actin cytoskeleton remodeling. I found decreased polyglycylation and higher glutamylation level of tubulin in TTLL8 knockout mice testes and spermatozoa. Antagonistic regulation between glycylation and glutamylation of tubulins may generate tubulin diversity. (2) I found that Clathrin regulates actin cytoskeleton remodeling through the direct inhibition of FilGAP.
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Report
(5 results)
Research Products
(4 results)
