| Project/Area Number |
22770198
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
SAKAKI Kenjiro 東京女子医科大学, 医学部, 講師 (70509968)
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHINA Sawako 東京女子医科大学, 医学部, 助教 (00424672)
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | タンパク質分解 / 小胞体ストレス / 品質管理 / NMD / 小胞体 / 品質管理機構 |
|---|
| Research Abstract |
Accuracy of gene expression is guaranteed by quality control systems that inspect their transcriptional or translational products at the multiple steps through the process of gene expression. And "interplays" of each quality control system give the adaptation of organs to diverse environmental changes and stress conditions. Herein, we revealed that nonsense-mediated RNA decay(NMD), one of RNA surveillance systems, significantly functions in ER quality control system(ERQC) that inspect folding status of secretive proteins in the endoplasmic reticulum(ER).
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