Mechanisms of the spindle assembly checkpoint silencing by kinetochore stretching
| Project/Area Number |
22770200
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | Japanese Foundation For Cancer Research |
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Principal Investigator |
UCHIDA Kazuhiko 公益財団法人がん研究会, がん研究所実験病理部, 研究員 (40380555)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 細胞周期 / 紡錘体チェックポイント / 細胞分裂 / 動原体 / 紡錘体微小管 / 細胞生物学 |
|---|
| Research Abstract |
Kinetochore stretching, repetitive cycles of kinetochore extension and recoiling, inactivates the spindle assembly checkpoint after biorientation. At the same time, tension is applied across sister kinetochores by intact pulling force. It is thought that this tension also inactivates the checkpoint. In this study, I demonstrated that kinetochore stretching-dependent checkpoint silencing is independent from tension-dependent checkpoint silencing
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Report
(4 results)
Research Products
(4 results)
