Molecular dissection of sister chromatid cohesion
| Project/Area Number |
22770201
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Cell biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
SHINTOMI Keishi 独立行政法人理化学研究所, 平野染色体ダイナミクス研究室, 研究員 (60462694)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 染色体 / 姉妹染色分体 / コヒーシン / コンデンシン / カエル卵無細胞系 / 姉妹染色分体接着 |
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| Research Abstract |
Cohesin is a protein complex essential for sister chromatid cohesion. The goal of this study is to understand molecular basis behind the cohesion process. My initial approach using the cohesin complexes reconstituted from recombinant subunits fell through because of some technical reasons. Unexpectedly, I have found that balancing action between cohesin and condensin, which is required for chromosome condensation, determines shapes of metaphase chromosomes in a cell-free system from frog eggs.
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Report
(3 results)
Research Products
(11 results)
