Functional analysis of signaling molecules regulating fate decision of epidermis and neural tissue in embryonic ectoderm

• Project/Area Number: 22770211
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Developmental biology
• Research Institution: Kyoto University
• Principal Investigator: KUSAKABE Morioh 京都大学, 大学院・生命科学研究科, 助教 (80378843)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: シグナル伝達 / 発生・分化 / 発生

Research Abstract

In vertebrates, embryonic ectoderm is fated to give rise to epidermis or neural tissue. We have shown that a novel one-pass transmembrane protein EIG121L promotes epidermal differentiation of Xenopus embryonic ectoderm. Our analyses also suggested that EIG121L binds to BMP receptors and has a positive role in BMP signaling during epidermal differentiation.

Research Products

• [Journal Article] Identilication and characterization of Xenopus kctdl5, an ectodermal gene repressed by the FGF pathway (2012)
  • Author(s): Takahashi, C., Suzuki, T., Nishida, E., Kusakabe, M.
  • Journal Title: International Journal of Developmental Biology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] The kinase SGK1 in the endoderm and mesoderm promotes ectodermal survival by down-regulating components of the death-inducing signaling complex (2011)
  • Author(s): Endo, T., Kusakabe, M., Sunadome, K., Yamamoto, T. and Nishida, E
  • Journal Title: Sci. Signal Volume: 4 Issue: 156
  • DOI: 10.1126/scisignal.2001211
  • Peer Reviewed
• [Journal Article] A transmembrane protein EIG121L is required for epidermal differentiation during early embryonic development (2011)
  • Author(s): Araki, T., Kusakabe, M. and Nishida, E
  • Journal Title: J. Biol. Chem Volume: 286 Issue: 8 Pages: 6760-6768
  • DOI: 10.1074/jbc.m110.177907
  • Peer Reviewed
• [Journal Article] A transmembrane protein EIG121L is required for epidermal differentiation during early embryonic development. (2011)
  • Author(s): Araki, T., Kusakabe M., Nishida, E.
  • Journal Title: Journal of Biological Chemistry Volume: 286 Pages: 6760-6768
  • Peer Reviewed
• [Journal Article] Identification and characterization of Xenopus kctd15 an ectodermal gene repressed by the FGF pathway.
  • Author(s): Takahashi, C., Suzuki, T., Nishida, E., and Kusakabe, M.
  • Journal Title: Int. J. Dev. Biol. Volume: (in press)
  • Peer Reviewed
• [Presentation] Essential role of new ectodermal genes in Xenopus early development (2011)
  • Author(s): 高橋千佳、鈴木俊康、西田栄介、日下部杜央
  • Organizer: 第63回日本細胞生物学会大会
  • Place of Presentation: 北海道大学
  • Year and Date: 2011-06-29
• [Presentation] A transmembrane protein EIG121L isrequired for epidermal differentiation during early embryonic development (2011)
  • Author(s): Tetsuro Araki, Morioh Kusakabe, Eisuke Nishida
  • Organizer: The 9th International Student Seminar
  • Place of Presentation: Shiran Kaikan, Kyoto University, Kyoto, Japan
  • Year and Date: 2011-03-08
• [Presentation] Identification and functional analysis of Ras-regulated genes in Xenopus embryos (2011)
  • Author(s): Chika Takahashi, Toshiyasu Suzuki, Morioh Kusakabe, Eisuke Nishida
  • Organizer: The 9th International Student Seminar
  • Place of Presentation: Shiran kaikan, Kyoto University, Kyoto, Japan
  • Year and Date: 2011-03-07
• [Presentation] Eisuke Nishida A novel regulator of the BMP pathway required for epidermal differentiation during early embryonic development (2010)
  • Author(s): Tetsuro Araki, Morioh Kusakabe
  • Organizer: 13th International Xenopus Conference
  • Place of Presentation: Fairmont Chateau Lake Louise, Alberta, Canada
  • Year and Date: 2010-09-13
• [Presentation] A Novel Regulator of the BMP Pathway Required for Epidermal Differentiation during Early Embryonic Development (2010)
  • Author(s): 荒木徹朗、日下部杜央、西田栄介
  • Organizer: 13th International Xenopus Conference
  • Place of Presentation: Fairmont Chateau Lake Louise, Lake Louise, Alberta, Canada.
  • Year and Date: 2010-09-13
• [Presentation] SGK1は細胞非自律的な抗アポトーシスシグナル伝達を仲介する (2010)
  • Author(s): 遠藤達矢, 日下部杜央, 砂留一範, 山本拓也, 西田栄介
  • Organizer: 第22回高遠シンポジウム
  • Place of Presentation: 高遠さくらホテル
• [Remarks]
  • URL: http://www.lif.kyoto-u.ac.jp/labs/signal/